The benefit of supplements?
Here are some concerns:
- Unless there is a BLOOD TEST which properly shows improvements and clinical placebo controlled study results to confirm this effect – as is the case with eg. Omega3 or Vitamin D – supplementation with “Vitamins” maybe questionable. In general, a shot gun approach with synthetic multivitamins does not seem to have effects on your health.
- Research shows that many supplement do not get properly absorbed in the digestive track and that harmful side effects can occur.
- Most people consume random supplements at irregular times without a well designed protocol for their health.
- Herbal medicine is not supplementation! These powerful gifts of nature have to be prescribed by a professional!
- Very often random supplements and herbs are mixed together such as turmeric, vitamin B and other random herbs. The effects of each supplement may therefor even be impaired.
- Yes, our food is up to 40-80% less nutritional. The reasons are over-farming and monocultures and over-hybridization compared species and practices used 70 years ago. But unfortunately adding synthetic nutrients to our diet does often not show a benefit. Natural derived supplements may have benefits but testing and good digestive tract is mandatory.
Disclaimer:
The information provided on this website is for general informational purposes only and should not be considered as medical advice. Supplements, including vitamins, minerals, and herbal products, can have significant effects on your health and may interact with medications or existing health conditions. It is essential to consult with a qualified healthcare professional, such as your doctor or a registered dietitian, before starting any new supplement regimen. Furthermore, it is important not to exceed recommended dosages, as overdosing on supplements can be harmful and may lead to serious health issues. Always follow the advice of your healthcare provider to ensure that any supplements you take are safe and appropriate for your specific health needs.
Table of Contents
Supplements that are generally not beneficial
- Calcium supplement dangers
- Castor oil, Flax and other vegetable oil
- Fluoride
- Iodide
- Iron (Anemia)
- Glucosamine and Chondroitin and collagen
- Multivitamins
- Ascorbyl Palmitate
Supplements that may show benefits
- Apple Cider Vinegar
- Ahiflower
- Alpha-lipoic-acid
- B vitamins and natural sources
- Caprylic acid and MCT
- CoQ10
- Curcumin
- Fiber and Fructose intolerance
- Fish oil and omega3
- Glucosamine
- Herbal Medicine
- Hyaloronic acid
- Lutein
- Types of Magnesium, monoatomic
- Nattokinase
- Polyphenols and insulin
- Potassium supplements
- Probiotics
- Rosemary extract
- Saffron
- Vitamin C and the redox potentials
- Vitamin E and CoQ10
- Vitamin K
- Zeolites and EDTA
Supplements that are required
General Nutrition
- -Alcohol
- -Artificial sweeteners and sugar subsitutes
- – Coffee filtered vs espresso
- -Dieting
- -Fermented Foods
- -Gluten
- -Keto
- -Meat sources, why BEEF is so important
- Mustard Seeds
- Nuts
- -Ozone and Hormesis
- – “Superfoods”
- -Salt and other Minerals
- -Tea green vs black
- -Veganism-a discussion
- -Water
- Inflammatory Grains vs Rice
- -General Nutrition – How then should I eat?
Many people may lack sufficient intake of various nutrients, either due to their dietary choices, issues with absorption, or other health-related factors. The specifics can depend on the individual, their diet, and their location, but some commonly deficient nutrients include:
- Vitamin D: Many people do not get enough sunlight exposure to synthesize adequate amounts of Vitamin D, and it’s difficult to get enough from food alone.
- Omega-3 Fatty Acids: These are crucial for brain health and reducing inflammation, but many modern diets lack sufficient sources of Omega-3s.
- Vitamin B12: This is especially common among vegans and vegetarians, as B12 is primarily found in animal products.
- Iron: Deficiency is common, especially among menstruating women, and can lead to anemia if not addressed.
- Iodine: Many people who don’t eat seafood or use iodized salt can become deficient in this important nutrient for thyroid function.
- Calcium: Despite the emphasis on dairy for bone health, many people still fall short of their calcium needs.
- Vitamin A: Especially prevalent in developing countries, deficiency can lead to vision issues.
- Magnesium: Essential for many biochemical reactions, yet many people don’t get enough.
- Zinc: Crucial for immune function, many people don’t meet their daily zinc needs.
- Folate: This B-vitamin is crucial for DNA synthesis and repair, but can be lacking, especially in pregnant women or those who consume a lot of alcohol.
Again, it’s important to note that these are general trends and may not apply to everyone. Always consult with a healthcare provider or registered dietitian to understand personal nutritional needs and deficiencies.
Do Joint supplements such as Glucosamine and Chondroitin have an effect on Arthritis?
30 trials – no effect over placebo
The average statistical outcome of Glucosamine show an increased relative risk of taking these supplements! Source Zhu 2018
Side effects may include:
Glucosamine supplements may affect blood sugar and insulin levels!
Constipation. Diarrhea. Drowsiness. Headache. Heartburn. Nausea. Rash.
A 2016 study of glucosamine and chondroitin enrolled 164 patients with knee pain due to osteoarthritis and gave half of them a combination of glucosamine and chondroitin; the other half received an identical placebo pill. The study was stopped early for an unusual reason: those taking the supplement actually reported worse symptoms than those taking a placebo. This raises the possibility that taking glucosamine and chondroitin might make your joints feel worse than doing nothing.
The dangers of collagen supplements!
Omega-3 and collagen work together!
Omega-3 fatty acids play a supportive role in collagen health by reducing inflammation, protecting against collagen breakdown, and promoting collagen synthesis. Collagen is a primary structural protein in connective tissues, skin, bones, and joints. Here’s how omega-3s support collagen health:
1. Anti-Inflammatory Effects Protect Collagen Integrity
- Chronic inflammation contributes to collagen breakdown, particularly in conditions affecting connective tissue, skin, and joints. Omega-3s (EPA and DHA) are well-known for their anti-inflammatory properties, as they help reduce levels of pro-inflammatory molecules like IL-6 and TNF-alpha. By reducing inflammation, omega-3s help protect collagen from degradation.
- Studies have shown that EPA and DHA can lower the production of matrix metalloproteinases (MMPs), enzymes that degrade collagen and other extracellular matrix proteins during inflammation. This helps preserve collagen structure, particularly in the skin and joints.
2. Stimulation of Collagen Synthesis
- Omega-3s support collagen synthesis through pathways that involve reducing oxidative stress. Oxidative stress can hinder collagen production by damaging fibroblasts, the cells responsible for collagen synthesis. Omega-3s, with their antioxidant properties, protect fibroblasts and enhance their collagen-producing activity.
- Some animal studies indicate that omega-3s may upregulate specific signaling pathways that promote collagen synthesis, such as the TGF-beta pathway, which is involved in tissue repair and collagen production.
3. Improved Skin Health and Elasticity
- Omega-3s are crucial for maintaining healthy skin, which relies on a strong collagen matrix for elasticity and strength. By reducing inflammation and protecting the skin barrier, omega-3s can help prevent collagen breakdown due to environmental stressors, such as UV exposure.
- Research has shown that omega-3 supplementation can improve skin elasticity, hydration, and smoothness, suggesting that these fatty acids help maintain a healthy collagen structure in the skin.
4. Joint Health and Cartilage Protection
- Collagen is a major component of cartilage, and omega-3s can help protect it by reducing inflammation in the joints. Omega-3s are often used in managing arthritis symptoms because they reduce pain and stiffness by limiting the inflammatory response that leads to cartilage breakdown.
- Studies on patients with rheumatoid arthritis have found that omega-3 supplementation can reduce joint pain and stiffness, partially due to the preservation of collagen and cartilage.
Sources of Omega-3s for Collagen Health
- Dietary Sources: Fatty fish (like salmon, mackerel, and sardines), flaxseed, chia seeds, and walnuts.
- Supplements: Fish oil or algae-based omega-3 supplements provide concentrated EPA and DHA, the active forms that impact collagen synthesis and protection most directly.
Conclusion
Omega-3s support collagen health by reducing inflammation, protecting against collagen breakdown, and promoting fibroblast function for collagen synthesis. This contributes to better skin elasticity, joint integrity, and overall connective tissue health.
FOR THIS REASON CHOOSE TESTED AND VALIDATED PRODUCTS FROM ZINZINO – BOOzT (COMING SOON)
The danger of Calcium supplements!
Typically you get all the calcium you need by eating a varied and balanced diet. Foods rich in Calcium are easy to find. In contrast, calcium supplements could be harmful. Calcium is one component of the most common type of human kidney stones as calcium oxalate.
The findings, based on records from more than 2,000 patients, add to evidence linking Calcium supplements to kidney stone risk. We no longer recommend dietary calcium restriction as this may lead to bone demineralization and an increase in stone formation!
Vitamin D and risks of overdosing
Warning- Vitamin D gel caps turn rancid
Vitamin D (a hormone) is another vital nutraceutical. The reality is that most humans even below the 36th latitude do not get enough sun exposer to make natural Vitamin D. Only cold water fish contain any reasonable amounts of D3.
Here’s a table of foods rich in vitamin D3 (cholecalciferol), showing micrograms per 100 grams of each food source. These values can vary slightly depending on food preparation and source.
Food | Vitamin D3 (µg per 100g) | Comments |
---|---|---|
Cod liver oil | 250 µg | One of the richest sources of vitamin D3. |
Salmon (wild) | 10-18 µg | Wild salmon generally has higher levels. |
Salmon (farmed) | 8-10 µg | Farmed salmon has slightly lower D3 levels. |
Herring | 16-22 µg | Varies by preparation, such as pickling. |
Sardines (canned) | 4-8 µg | High in omega-3s as well as vitamin D3. |
Mackerel | 10 µg | Another oily fish, high in D3. |
Tuna (canned in oil) | 3-6 µg | Provides D3 and convenient for storage. |
Rainbow trout | 16 µg | A freshwater fish with substantial D3 levels. |
Egg yolk | 2-3 µg | D3 is concentrated in the yolk, not whites. |
Beef liver | 1.1 µg | Also contains vitamin A and iron. |
Fortified milk | 1-2 µg | Fortified in some countries for daily intake. |
Fortified orange juice | 1-2 µg | Commonly fortified with D3 for accessibility. |
Fortified cereals | 1-4 µg | Varies widely based on brand and type. |
Mushrooms (UV-exposed) | 10-20 µg (D2) | Contains vitamin D2, which can convert to D3. |
Notes:
- Oily fish like salmon, sardines, and mackerel are among the best natural sources of vitamin D3.
- Fortified foods (milk, orange juice, cereals) are convenient sources, especially for those with limited sunlight exposure.
- Mushrooms naturally contain vitamin D2, which can partially convert to D3 in the body, but they are not a direct source of D3.
Vitamin D supplements are available in two forms: Vitamin D2 (ergocalciferol) and Vitamin D3 (cholecalciferol). Here’s a comparison between the two forms and the different available formulations:
Vitamin D2 (Ergocalciferol) is generally not recommended
1. Source: It is primarily obtained from fungal and plant sources, making it suitable for vegetarians and vegans.
2. Efficacy: Generally considered less effective in raising and maintaining Vitamin D levels in the blood compared to D3.
3. Cost: Usually less expensive compared to D3.
Vitamin D3 (Cholecalciferol) in pill form is preferred
1. Source: Derived mostly from animal sources like fish oil and lanolin (sheep’s wool), but there are also lichen-based D3 supplements for vegans.
2. Efficacy: More effective in raising and maintaining Vitamin D levels due to its longer duration in the bloodstream and higher potency.
Gel vs Pill
– Gel Capsules: – have a risk of rancidity!!
– Typically contain oil (like olive oil) along with the Vitamin D, which can enhance absorption as Vitamin D is fat-soluble.
– Some people find gel capsules easier to swallow than pills but typically pills are very small and the risk of overdosing maybe higher on gel caps.
– Pills (Tablets/Caplets):
– May contain binders and fillers, which could potentially interfere with absorption, especially in people with certain food sensitivities or allergies.
– Typically have a longer shelf life and are usually less expensive than gel capsules.
Regardless of the chosen supplement, it is crucial to adhere to recommended dosages to avoid adverse effects like hypercalcemia.
Overdosing on Vitamin D can lead to Vitamin D toxicity, also known as hypervitaminosis D. This occurs usually from the long-term intake of high doses of Vitamin D supplements, not from dietary intake or sun exposure. The recommended daily amount of Vitamin D is 400–800 IU/day, but the safe upper limit is generally considered to be 4,000 IU/day for most adults.
Symptoms of Vitamin D Overdose
– Hypercalcemia: Excess Vitamin D can lead to high levels of calcium in the blood, causing nausea, vomiting, weakness, and serious complications like kidney damage.
– Bone Pain: Despite being essential for bone health, too much Vitamin D can cause bone pain.
– Nephrocalcinosis: The deposition of calcium and phosphate in the kidneys, potentially leading to kidney failure.
– Neurological Symptoms: Confusion, drowsiness, and even coma in severe cases due to high calcium levels affecting the nervous system.
– Gastrointestinal Distress: Nausea, vomiting, and abdominal pain.
Treatment of overdose
Treatment usually involves stopping Vitamin D intake and restricting dietary calcium. In severe cases, medical intervention may be necessary to lower calcium levels, such as through the use of corticosteroids or bisphosphonates.
Because vitamin D is fat-soluble and stored in the body, it can take some time for the body to eliminate excess amounts. The half-life of vitamin D in the body is estimated to be about 15 days, but complete resolution of vitamin D toxicity may take several weeks to months, depending on the extent of the overdose and the individual’s overall health.
Overdosing on Vitamin D can contribute to the formation of stones, particularly kidney stones.
How stone formation Happens
- High Calcium Levels: Vitamin D helps the body absorb calcium. Too much Vitamin D leads to elevated levels of calcium in the blood, a condition known as hypercalcemia.
- Calcium Deposits: The excess calcium is then excreted by the kidneys. However, high levels of calcium in the urine can lead to the formation of calcium stones, typically calcium oxalate or calcium phosphate stones.
Impact of Stone Formation
Kidney stones can cause significant discomfort and pain, typically manifesting as sharp pain in the lower back or abdomen, hematuria (blood in urine), and frequent urination. In severe cases, if stones are left untreated, it can lead to renal damage or failure.
Prevention and Management
- Stay Hydrated: Drinking plenty of fluids can help prevent the formation of kidney stones by diluting the concentration of calcium in the urine.
- Regular Monitoring: People taking high doses of Vitamin D supplements should have regular blood tests to monitor Vitamin D and calcium levels to avoid hypercalcemia.
- Balanced Diet: Maintaining a balanced intake of calcium, avoiding excess sodium, and moderating intake of high-oxalate foods like spinach and nuts can also reduce the risk of stone formation.
To avoid overdosing on Vitamin D:
1. **Don’t Exceed the Recommended Dose:** Stick to the recommended daily intake unless advised otherwise by a healthcare provider.
2. **Monitor Supplement Intake:** Be mindful of all supplements you take and whether they contain Vitamin D.
3. **Regular Monitoring/testing:** If you are on high doses of Vitamin D supplements for medical reasons, regular monitoring of blood levels is crucial to avoid toxicity.
It’s also crucial to ensure a balanced intake of other minerals and vitamins, as they can interact with Vitamin D metabolism and absorption. For example, adequate levels of Vitamin K are thought to help mitigate the risks of Vitamin D toxicity, and magnesium is necessary for the activation of Vitamin D in the body.
Always consult a healthcare or a qualified healthcare professional when considering changes to supplement dosages, especially for substances that can be harmful in excess.
Instead you should take your D3 supplements with 4 types of Magnesium! And by the way magnesium needs Vitamin D for absorption and vice versa (see below).
Vitamin D and sleep
While there is some weak evidence suggesting a link between vitamin D and sleep, more research is needed to fully understand the nature of this relationship. Additionally, individual responses to vitamin D supplementation can vary,
- Vitamin D and Sleep Patterns: Some research has indicated that individuals with lower levels of vitamin D may be more likely to experience sleep disturbances, such as difficulty falling asleep or staying asleep through the night.
- Vitamin D and Sleep Disorders: There is some evidence to suggest that vitamin D deficiency may be associated with an increased risk of certain sleep disorders, such as sleep apnea and restless leg syndrome. However, more research is needed to establish a clear causal relationship.
- Vitamin D and Circadian Rhythms: Vitamin D is believed to play a role in regulating circadian rhythms, which are the body’s internal clock that controls sleep-wake cycles. Disruptions in circadian rhythms can lead to sleep disturbances.
- Vitamin D Supplementation: Some studies have explored whether vitamin D supplementation can improve sleep quality, especially in individuals with low vitamin D levels. Results have been mixed, with some studies suggesting a potential benefit while others do not show a significant effect.
The timing of when you take cholecalciferol, which is a form of vitamin D, can matter to some extent, but it’s generally flexible and can depend on your personal preference and lifestyle. Here are some considerations (not peer reviewed studies):
- Absorption: Cholecalciferol (vitamin D3) is fat-soluble, which means it is better absorbed when taken with a meal that contains some dietary fat. So, taking it with a meal can enhance its absorption.
- Consistency: Consistency in the timing of your vitamin D supplementation can be more important than the specific time of day. If you choose to take it with breakfast, for example, try to do so consistently.
- Individual Variation: Some people find that taking vitamin D in the morning helps them feel more awake, while others prefer taking it in the evening. Individual responses can vary.
- Avoiding Interference: If you take other medications or supplements, be aware of potential interactions. For example, some medications or supplements can interfere with the absorption of vitamin D, so it’s a good idea to space them out if needed. Consult your healthcare provider or pharmacist for guidance if you’re unsure.
- Sunlight Exposure: If you’re also getting vitamin D from sunlight, your body’s natural production of vitamin D is influenced by the time of day. Exposure to sunlight in the morning or late afternoon is generally more effective for vitamin D synthesis compared to midday sun.
Vitamin D and sarcopenia
Vitamin D plays a significant role in muscle function and potentially in increasing muscle mass. Its effects on muscles are primarily attributed to its impact on calcium regulation and direct actions on muscle tissue. Here’s an overview of the mechanisms through which vitamin D can influence muscle mass and strength:
- Calcium Regulation: Vitamin D is crucial for calcium absorption in the gut. Adequate calcium levels are essential for proper muscle contraction and function. Without sufficient vitamin D, calcium absorption is impaired, which can lead to weaker muscle contractions and potentially to muscle weakness and decreased muscle mass.
- Direct Effects on Muscle Cells: Vitamin D receptors are present in muscle tissue, suggesting that vitamin D directly influences muscle cell growth and function. Activation of these receptors by vitamin D can stimulate muscle cell proliferation and differentiation, processes that are crucial for muscle growth and repair.
- Reduction in Muscle Degradation: Vitamin D may help in reducing muscle degradation and loss of muscle mass, particularly in older adults or those with vitamin D deficiency.
- Influence on Muscle Strength: Several studies have shown a correlation between higher levels of vitamin D and increased muscle strength, particularly in older adults. Improved muscle strength can support more effective muscle building and maintenance.
- Hormonal Impact: Vitamin D may also influence muscle mass indirectly through its effects on other hormones, including testosterone, which has a role in muscle growth and repair.
- Improvement in Physical Performance: Adequate vitamin D levels are associated with improved overall physical performance, which can enable more effective exercise and muscle strengthening activities.
- Prevention of Muscle Wasting: In conditions like sarcopenia (age-related muscle loss) and in various musculoskeletal disorders, vitamin D supplementation has been shown to be beneficial in preventing muscle wasting and decline in muscle function.
Clinical Considerations:
- Deficiency and Supplementation: Vitamin D deficiency is relatively common and is associated with muscle weakness and poor muscle health. Supplementation in deficient individuals can lead to improvements in muscle strength and mass.
- Optimal Levels: It’s important to maintain optimal levels of vitamin D for muscle health, but excessive supplementation should be avoided as it can lead to toxicity and adverse health effects.
- Individual Variability: The response to vitamin D can vary among individuals, and factors like age, baseline vitamin D levels, and overall health status can influence its effectiveness in muscle mass maintenance and growth.
In summary, vitamin D contributes to muscle health through its roles in calcium regulation, direct effects on muscle cells, hormonal impacts, and physical performance. Maintaining adequate vitamin D levels is important for muscle strength and mass, particularly in populations at risk for deficiency.
Osteoporosis
Even with addition of Vitamin D, most studies show an increased relative risk!
Multivitamins
27+ studies that covered more than 450,000+ participants and found that multivitamins do not benefit your health.
Researchers concluded that multivitamins don’t reduce the risk for heart disease, cancer, cognitive decline (such as memory loss and slowed-down thinking) or an early death. They also noted that in prior studies, they contain vitamin E and beta-carotene supplements that appear to be harmful, especially at high doses.
In summary, most Multivitamins are poorly absorbed (partly because of your omega3 deficiency) and because they are synthetic they may post harm to your body. Many of its ingredients may be oxidized or rancid. However there are natural sourced well balanced vitamins available that may be of benefit.
Castor oil and other seed oils
In general vegetable seed, grain or nut oils can contain omega3 – alpha linolenic acid. With a few exceptions (such as flax) they contain a very high omega6/3 ratio. In addition omega3 oxidizes much quicker than omega6.
Omega-3 fatty acids are more prone to oxidation than omega-6 fatty acids due to their chemical structure. Omega-3 fatty acids have a higher number of double bonds compared to omega-6 fatty acids. The double bonds in the fatty acid chains make them more susceptible to oxidation reactions.
The most common omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have five and six double bonds, respectively, whereas the most common omega-6 fatty acid, linoleic acid, has only two double bonds. This difference in the number of double bonds makes omega-3 fatty acids more vulnerable to oxidative damage.
To prevent the oxidation of omega-3 fatty acids, it is essential to store them properly. Keep omega-3 supplements and oils containing high amounts of omega-3 fatty acids in a cool, dark place, preferably in an airtight container or in the refrigerator. It’s also important to consume them before their expiration date.
Omega-3 supplements contain antioxidants, such as vitamin E or astaxanthin, which can help protect the fatty acids from oxidation. However this has been proven to be very inefficient. Zinzino contains a natural proprietary phenolic stabilizer and has been third-party tested for purity and quality can help ensure that you are getting a high-quality, stable omega-3 supplement.
Castor oil has been used orally to relieve constipation or to evacuate the bowel and reduce inflammation. When the Ricinoleic acid (the main ingredient of castor oil) oxidizes, it forms hydroperoxides, which are unstable and can further break down into secondary oxidation products. The secondary oxidation products include aldehydes, ketones, and short-chain fatty acids. The secondary oxidation products formed during the lipid oxidation process, such as aldehydes, ketones, and short-chain fatty acids, can potentially have negative effects on health when consumed in significant amounts. Some of these compounds are considered toxic and can contribute to various health issues.
For example, certain aldehydes produced during lipid oxidation, such as acrolein, malondialdehyde, and 4-hydroxynonenal, have been linked to increased inflammation and oxidative stress in the body. These conditions can contribute to the development of chronic diseases, such as cardiovascular disease, neurodegenerative diseases, and cancer.
However if castor oil is freshly used it can have good Analgesic and Anti-inflammatory properties. Ricinoleic acid, the primary component of castor oil, has been studied for its potential medicinal properties, mainly due to its anti-inflammatory and analgesic (pain-relieving) effects. However, while there are several anecdotal claims and traditional uses, scientific studies are somewhat limited.
Other supplements that do show evidence of health benefits when used properly.
Apple cider vinegar -ACV
Apple cider vinegar (ACV) has been touted as a weight loss aid by some, but scientific evidence supporting this claim is limited. There are a few studies that suggest ACV may have modest effects on weight loss, mainly through its impact on satiety and blood sugar control.
A small study in 2009 published in the journal Bioscience, Biotechnology, and Biochemistry found that participants who consumed 1-2 tablespoons of apple cider vinegar daily for 12 weeks experienced a slight reduction in body weight, body fat percentage, and waist circumference compared to a control group.
Another study published in the European Journal of Clinical Nutrition found that consuming vinegar with a high-carbohydrate meal could increase feelings of fullness, leading to a reduced caloric intake throughout the day.
Apple cider vinegar may help regulate blood sugar levels by slowing down the digestion of carbohydrates, which can contribute to better blood sugar control and potentially support weight loss.
However, it’s essential to note that the effects of ACV on weight loss are modest and cannot replace a balanced diet and regular exercise for effective and sustainable weight loss. Additionally, excessive consumption of apple cider vinegar can cause negative side effects, such as tooth enamel erosion and gastrointestinal issues. Always dilute ACV with water (or take pills) before consumption and consult with a healthcare professional before incorporating it into your weight loss plan.
ACV appears to have a profound effect on sugar metabolism and increases fullness and reduces calorie intake. Apple cider vinegar may promote fullness, which can decrease calorie intake by its appetite-suppressing effects; apple cider vinegar has also been shown to slow the rate at which food leaves your stomach.
- Kondo, T., Kishi, M., Fushimi, T., & Ugajin, S. (2009). Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects. During the 12-week treatment period Body weight, BMI, visceral fat area, waist circumference, and serum triglyceride levels were significantly lower in both vinegar intake groups than in the placebo group. Bioscience, Biotechnology, and Biochemistry, 73(8), 1837-1843. doi: 10.1271/bbb.90231
- Johnston, C. S., Kim, C. M., & Buller, A. J. (2004). Vinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetes. Diabetes Care, 27(1), 281-282. doi: 10.2337/diacare.27.1.281Effects of vinegar (□) and placebo (⧫) on plasma glucose
- Khezri, S. S., Saidpour, A., & Hosseinzadeh, Z. (2014). Effect of vinegar on blood glucose, insulin, and insulin resistance in type 2 diabetic subjects: A randomized controlled trial. Vinegar compared to placebo (1) increased forearm glucose uptake (p = 0.0357), (2) decreased plasma glucose (p = 0.0279), insulin (p = 0.0457), and triglycerides (p = 0.0439) Journal of Diabetes and Metabolic Disorders, 13(1), 1-5. doi: 10.1186/2251-6581-13-27
- Budak, N. H., Kumbul Doguc, D., Savas, C. M., Seydim, A. C., Kok Tas, T., & Ciris, M. I. (2014). Effects of apple cider vinegars produced with different techniques on blood lipids in high-cholesterol-fed rats. Apple cider vinegars, regardless of the production method, decreased triglyceride and VLDL levels in all groups when compared to animals on high-cholesterol diets without vinegar supplementation. Journal of Agricultural and Food Chemistry, 62(22), 5118-5123. doi: 10.1021/jf500719k
- Shishehbor, F., Mansoori, A., & Shirani, F. (2017). Vinegar consumption can attenuate postprandial glucose and insulin responses; a systematic review and meta-analysis of clinical trials. studies revealed a significant mean glucose and insulin area under the curve (AUC) reduction in participants who consumed vinegar compared with the control group (standard mean difference=-0.60, 95%CI -1.08 to -0.11, p=0.01 and -1.30, 95%CI -1.98 to -0.62, p<0.001, respectively) Diabetes Research and Clinical Practice, 127, 1-9. doi: 10.1016/j.diabres.2017.01.021
These studies suggest that consuming apple cider vinegar may have a beneficial effect on weight loss, insulin sensitivity, blood glucose levels, and blood lipid levels. However, it is important to note that more research is needed to fully understand the effects of apple cider vinegar on weight loss and overall health. It is also important to use caution when consuming vinegar, as it can cause irritation to the throat and stomach if consumed in large amounts. In that context it is therefor recommended to intake ACV in pill form.
In addition ACV contains many other ingredients such as phenolic acid anti-oxidants.
Coenzyme Q10
Coenzyme Q10 (CoQ10) is a naturally occurring substance in the body that is found in the mitochondria, which are the energy-producing structures within cells. CoQ10 is involved in the production of ATP, which is the main source of energy for cells.
In addition to its role in energy production, CoQ10 also has antioxidant properties, which means it helps protect cells from damage caused by free radicals. It is also thought to have anti-inflammatory effects and may play a role in immune function.
CoQ10 is found in small amounts in a variety of foods, including fatty fish, organ meats, and whole grains. It is also available as a dietary supplement in the form of capsules, tablets, and softgels. CoQ10 supplements are sometimes used to treat a variety of health conditions, including heart disease, high blood pressure, and migraines, although more research is needed to determine their effectiveness.
Thus, 15mg of CoQ10 are included in Zinzino Xtend per serving.
Magnesium:
Magnesium is probably the most important mineral supplement we need to add to our diet. Because of intense farming and monocultures our food is Magnesium deficient. In addition many people cannot absorb Magnesium from plants because of their poor digestion. So the combination of Omega3/VitaminD/Magnesium are the pillar of supplementation.
Low magnesium could mean
• Blood sugar imbalance
• Constipation
• Headache
• Inability to cope with stress
• Irritability
• Low energy / fatigue
• Muscle cramps / spasms
• Nausea
• PMS
• Sleep problems
• Weakness
Magnesium is an essential mineral that plays a critical role in various bodily functions, including muscle and nerve function, energy production, and bone health. There are several plants and plant-based foods that are rich in magnesium. Some of them include:
- Dark leafy greens: Spinach, kale, Swiss chard, and collard greens are excellent sources of magnesium.
- Nuts and seeds: Almonds, cashews, peanuts, pumpkin seeds, sunflower seeds, and flaxseeds are high in magnesium.
- Legumes: Beans, lentils, and chickpeas are rich in magnesium.
- Whole grains: Brown rice, quinoa, barley, and oats contain significant amounts of magnesium.
- Dark chocolate: High-quality dark chocolate with a high percentage of cocoa (70% or more) is a good source of magnesium.
- Avocado: Avocados are rich in magnesium, as well as other essential nutrients like potassium and healthy fats.
- Bananas: Although known for their potassium content, bananas also provide a decent amount of magnesium.
There are several reasons why magnesium deficiency is common:
- Soil depletion: Industrial farming practices have led to a depletion of essential minerals, including magnesium, in the soil. As a result, the plants grown in these soils may have lower magnesium content.
- Processed foods: The modern diet often relies heavily on processed foods, which typically have lower magnesium levels than whole foods.
- Poor absorption: Some factors can affect magnesium absorption in the body, such as gastrointestinal disorders, kidney issues, or excessive consumption of alcohol.
- Increased requirements: Certain conditions, like stress, intense physical activity, or medical conditions like diabetes, can increase the body’s demand for magnesium, leading to a deficiency if not adequately addressed through diet or supplementation.
- Medications: Some medications, such as diuretics or proton pump inhibitors, can interfere with magnesium absorption or cause increased excretion of magnesium through urine.
To prevent magnesium deficiency, it’s important to consume a balanced diet that includes magnesium-rich foods, and consider supplementation if necessary. It’s always a good idea to consult a healthcare professional for personalized guidance on addressing nutrient deficiencies.
Studies now show an intake of >350mg of Mg in at least 4 types of salts is advised.
Excess Magnesium consumption over 1000mg is not typically necessary and can have side effects such as nausea, diarrhea, low blood pressure, muscle weakness, and fatigue. However stone formation is unlikely. In this study by Johannson 1985 Magnesium can even be used to regulate calcium stones. “The magnesium/calcium ratio in the urine increased and approached a value earlier found in healthy subjects without stone disease. Urinary citrate increased on therapy when analysed after three years of treatment. The mean stone episode rate decreased from 0.8 to 0.08 stones/year on treatment and 85% of the patients remained free of recurrence during follow-up, whereas 59% of the patients in the control group continued their stone formation. “
Studies on Magnesium and Mood
Several studies have investigated the relationship between magnesium and mood, particularly in the context of depression and anxiety. Here are a few notable studies:
Source: Serefko, A., Szopa, A., Wlaź, P., Nowak, G., Radziwoń-Zaleska, M., Skalski, M., & Poleszak, E. (2016). Magnesium in depression. Pharmacological Reports, 65(3), 547-554.
- A 2008 study investigated the association between magnesium intake and depressive symptoms in a large sample of US adults. The study found that low magnesium intake was associated with a higher risk of depressive symptoms, suggesting a potential role for magnesium in the prevention and management of depression.
Source: Eby, G. A., & Eby, K. L. (2010). Rapid recovery from major depression using magnesium treatment. Medical Hypotheses, 67(2), 362-370.
Source: Tarleton, E. K., Littenberg, B., MacLean, C. D., Kennedy, A. G., & Daley, C. (2017). Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PloS One, 12(6), e0180067.
These studies indicate a potential link between magnesium and mood, particularly in the context of depression. However, more research is needed to fully understand the underlying mechanisms and to establish optimal dosage and treatment protocols. As always, consult a healthcare professional before starting any new supplement or treatment, as they can provide personalized guidance based on your specific health needs and concerns.
Which Magnesium should I take?
You should take a variety of Magnesium salts to ensure bioavailability. Taking a variety of magnesium salts may indeed increase bioavailability and help ensure that the body is receiving adequate amounts of magnesium. Different magnesium salts can have varying levels of absorption and can affect the body in different ways, so combining them may provide a more comprehensive approach to magnesium supplementation.
Some common forms of magnesium supplements include:
- Magnesium citrate: This form of magnesium has good bioavailability and is often used to support digestion and relieve constipation.
- Magnesium oxide: Magnesium oxide has a lower bioavailability than other forms of magnesium, but it contains a higher percentage of elemental magnesium. This makes it useful for those who require larger doses of magnesium, though its absorption might be less efficient.
- Magnesium glycinate: This form of magnesium is bound to the amino acid glycine and is considered to have good bioavailability. Magnesium glycinate is often recommended for individuals with a sensitive digestive system, as it tends to be gentle on the stomach and less likely to cause diarrhea.
- Magnesium taurate: Magnesium taurate combines magnesium with the amino acid taurine, which may provide synergistic cardiovascular benefits and improved absorption.
- Magnesium malate: This form of magnesium is bound to malic acid, a compound found in fruits and involved in energy production. Magnesium malate may be particularly beneficial for individuals with chronic fatigue syndrome or fibromyalgia.
- Magnesium threonate: This form of magnesium has been shown to cross the blood-brain barrier more effectively, making it potentially useful for supporting brain health and cognitive function.
By taking a combination of these magnesium salts, one may optimize magnesium absorption and benefit from the unique properties of each form. However, it is essential to consult with a healthcare professional before starting any new supplement regimen, especially if you are taking multiple forms of magnesium. A healthcare provider can help determine the appropriate dosage and forms of magnesium for your individual needs and health goals.
Magnesium Taurate
Magnesium taurate is a compound that combines magnesium, an essential mineral, with taurine, an amino acid. This particular form of magnesium is believed to offer specific health benefits due to the combination of these two components. Some of the potential benefits of magnesium taurate include:
- Cardiovascular health: Both magnesium and taurine have been linked to supporting cardiovascular health. Magnesium is known to help regulate blood pressure, reduce the risk of arrhythmias, and support overall heart function. Taurine, on the other hand, has been shown to have beneficial effects on blood pressure, heart muscle function, and blood vessel function. The combination of magnesium and taurine in magnesium taurate may offer synergistic cardiovascular benefits.
- Stress and anxiety reduction: Magnesium has been found to have calming effects on the nervous system and may help alleviate stress and anxiety. Taurine has also been reported to have potential anxiolytic effects. Magnesium taurate may provide a combined effect in reducing stress and anxiety.
- Improved sleep: Magnesium is involved in regulating sleep and has been shown to help improve sleep quality in some individuals. Taurine also plays a role in the regulation of sleep-wake cycles. Magnesium taurate may help support healthy sleep patterns and improve overall sleep quality.
- Neuroprotection: Both magnesium and taurine have neuroprotective properties, and their combination in magnesium taurate may provide additional benefits. Magnesium is involved in many neuronal processes and can help protect against excitotoxicity, a phenomenon that causes damage to nerve cells. Taurine is also known to have neuroprotective effects, including protection against oxidative stress and the regulation of intracellular calcium levels.
- Enhanced absorption: Magnesium taurate is considered to have better bioavailability compared to other forms of magnesium, such as magnesium oxide or magnesium citrate. This means that the body may more efficiently absorb magnesium when it is combined with taurine, leading to potentially greater benefits.
As with anything Magnesium supplementation should be based on an individual’s dietary intake, health status, and specific health goal.
Mg Taurate showed significant effects on lowering both systolic and diastolic blood pressure.
Magnesium glycinate is a chelated form of magnesium, where the magnesium ion is bound to the amino acid glycine. This form of magnesium is known for its high bioavailability and is often recommended for individuals with sensitive digestive systems, as it is less likely to cause gastrointestinal side effects such as diarrhea. While there are fewer specific studies focused solely on magnesium glycinate, there is research on magnesium supplementation in general that can provide insights into its potential benefits.
- Sleep improvement: A study published in the Journal of Research in Medical Sciences in 2012 found that magnesium supplementation improved insomnia-related symptoms in older adults. Although the study used magnesium oxide, it is possible that magnesium glycinate, with its higher bioavailability and gentler effect on the stomach, may also provide sleep-related benefits (Abbasi et al., 2012).
- Anxiety and stress reduction: A systematic review published in 2017 examined the effects of magnesium supplementation on subjective anxiety and stress. The review concluded that magnesium could have a positive impact on subjective anxiety and stress, particularly for those with a magnesium deficiency or high levels of stress (Boyle et al., 2017). Magnesium glycinate, with its high bioavailability, could potentially provide these benefits.
- Blood pressure regulation: A meta-analysis published in Hypertension in 2012 found that magnesium supplementation could effectively lower blood pressure in individuals with high blood pressure (Kass et al., 2012). While the meta-analysis did not focus specifically on magnesium glycinate, its high bioavailability may make it a suitable option for magnesium supplementation to support blood pressure regulation.
- Migraine prevention: A systematic review and meta-analysis published in 2016 in the journal Headache found that magnesium supplementation could be an effective preventative treatment for migraines (Chiu et al., 2016). Magnesium glycinate may provide similar benefits due to its high bioavailability and good tolerability.
It’s important to note that more specific research on magnesium glycinate is needed to fully understand its unique benefits and properties. As always, consult with a healthcare professional before starting any new supplement regimen, particularly if you have existing health conditions or are taking other medications.
Magnesium L-aspartate is a form of magnesium salt where magnesium is bound to the amino acid L-aspartic acid. This chelated form of magnesium has been suggested to offer improved bioavailability and absorption compared to other magnesium salts such as magnesium oxide. Magnesium L-aspartate is used as a dietary supplement to support various aspects of health, including:
- Muscle function: Magnesium is essential for muscle function and plays a key role in muscle contraction and relaxation. Magnesium supplementation, including magnesium L-aspartate, may help maintain proper muscle function and prevent muscle cramps or spasms.
- Energy production: Magnesium is involved in the production of adenosine triphosphate (ATP), the primary energy currency in cells. By supporting energy production, magnesium L-aspartate may help reduce fatigue and increase physical performance.
- Nervous system function: Magnesium is crucial for the proper functioning of the nervous system, as it influences the transmission of nerve impulses and the release of neurotransmitters. Magnesium L-aspartate may help support the nervous system and promote optimal brain function.
- Bone health: Magnesium is an essential mineral for maintaining bone health, as it contributes to bone mineralization and the regulation of calcium levels in the body. Supplementing with magnesium L-aspartate could help support overall bone health.
- Cardiovascular health: Magnesium is known for its role in maintaining healthy blood pressure levels and heart function. Magnesium L-aspartate, with its potentially higher bioavailability, may help support cardiovascular health.
Most studies on magnesium supplementation examine different forms of magnesium salts rather than focusing on one specific form. Here are a few studies that have investigated magnesium L-aspartate:
- In a 2000 study published in the journal Arzneimittel-Forschung, researchers compared the bioavailability of magnesium L-aspartate hydrochloride with that of magnesium oxide in healthy volunteers. The study found that magnesium L-aspartate hydrochloride had significantly better bioavailability than magnesium oxide, suggesting that magnesium L-aspartate could be a more effective form for supplementation (Lindberg et al., 2000).
- In a study published in the journal Magnesium Research in 1996, the effects of magnesium L-aspartate hydrochloride supplementation on muscle strength were investigated in patients with chronic fatigue syndrome. The study found that magnesium L-aspartate hydrochloride supplementation resulted in a significant increase in muscle strength and endurance in these patients (Cox et al., 1996).
While these studies provide some insights into the potential benefits of magnesium L-aspartate, more research is needed to fully understand its unique properties and effectiveness. It’s important to consult a healthcare professional before starting any new supplement regimen, particularly if you have existing health conditions or are taking other medications.
References: Cox, I. M., Campbell, M. J., & Dowson, D. (1996). Red blood cell magnesium and chronic fatigue syndrome. The Lancet, 347(9004), 757-758.
Lindberg, J. S., Zobitz, M. M., Poindexter, J. R., & Pak, C. Y. (2000). Magnesium bioavailability from magnesium citrate and magnesium oxide. Journal of the American College of Nutrition, 9(1), 48-55.
In summary: There are limited studies specifically focusing on a specific magnesium salt; One should always consider taking a variety of different forms of Magnesium as these effects and bioavailability may vary from person to person!
Magtein™ (Magnesium L-threonate)
Magtein™ is indeed a patented form of magnesium, specifically known as magnesium L-threonate. This compound was developed based on research that suggested it could effectively increase the levels of magnesium in the brain. Magnesium L-threonate is particularly noted for its ability to cross the blood-brain barrier, a unique characteristic that sets it apart from other forms of magnesium supplements.
Magnesium L-threonate contains about 8-9% elemental magnesium by weight. Therefore, if you take 2 grams (2000 mg) of Magnesium L-threonate, it provides approximately 144 to 180 mg of elemental magnesium.
This percentage is specific to the magnesium L-threonate compound due to its unique molecular structure where the magnesium ion is chelated to threonic acid (a derivative of vitamin C). This formulation is designed not for maximizing the amount of elemental magnesium per dose but rather for improving the ability of magnesium to cross the blood-brain barrier and enhance its neurological benefits.
B vitamins and natural sources
B vitamins are crucial for many bodily functions, including energy production, brain function, and the synthesis and repair of DNA and RNA. Here are some good food sources of B vitamins:
- B1 (Thiamine): Whole grains, legumes, seeds, nuts, and pork are good sources of thiamine.
- B2 (Riboflavin): Milk, cheese, eggs, leafy green vegetables, lean meats, legumes, and nuts all contain riboflavin.
- B3 (Niacin): You can get niacin from poultry, fish, lean meats, nuts, and eggs. Also, legumes and enriched breads and cereals contain this vitamin.
- B5 (Pantothenic Acid): Almost all foods contain small amounts of pantothenic acid, but whole grains, legumes, meat, and eggs are particularly rich sources.
- B6 (Pyridoxine): Good sources include meats, fish, poultry, legumes, tofu and other soy products, bananas, and nuts.
- B7 (Biotin): Biotin is found in a wide range of foods, but particularly in organ meats, eggs, fish, seeds, nuts, and certain vegetables like sweet potatoes.
- B9 (Folate): Folate is abundant in green leafy vegetables, legumes, seeds, liver, poultry, eggs, cereals and citrus fruits.
- B12 (Cobalamin): Animal-derived foods, such as meat, milk and other dairy products, and eggs, are the best sources of vitamin B12. Some plant-based milks and cereals are fortified with B12.
Factors like agricultural practices, animal feeding practices, and livestock breeds can have an impact on the nutritional content of meat, including B vitamins.
Red meat is an excellent source of vitamin B12 (cobalamin). In fact, animal-derived foods, including red meat, poultry, fish, eggs, and dairy products, are the primary sources of vitamin B12 in the diet. Vitamin B12 is essential for maintaining proper nerve function, brain health, and the production of red blood cells.
Among red meats, organ meats such as liver and kidney are particularly rich in vitamin B12. However, if you are a vegetarian or vegan, it’s important to find alternative sources of B12 or consider taking supplements, as plant-based foods generally do not contain significant amounts of this essential nutrient. Fortified cereals and plant-based milk alternatives are common sources of B12 for those following a plant-based diet.
It is essential to maintain a balanced diet and incorporate various food sources rich in B vitamins, such as whole grains, legumes, dairy products, eggs, and vegetables, to ensure adequate intake of these nutrients.
Bee pollen, it is also a source of B vitamins, but the amounts can vary widely depending on the plant source of the pollen. Keep in mind that bee pollen can cause allergic reactions in some people, so it’s important to start with small amounts to see how your body reacts.
Always remember that it’s best to get your vitamins from a varied, balanced diet whenever possible. In some cases, supplements may be necessary, but it’s always a good idea to consult with a healthcare professional before starting any new supplement regimen.
Baker’s yeast, also known as Saccharomyces cerevisiae, is a good source of B vitamins, particularly B1 (thiamine), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), and B9 (folate).
However, it’s important to note that baker’s yeast is not a source of B12 (cobalamin), which is typically found in animal-derived foods or fortified plant-based foods.
Nutritional yeast, which is a deactivated form of Saccharomyces cerevisiae, is also rich in B vitamins and is often fortified with B12. It has a nutty, cheesy flavor and can be sprinkled on foods like popcorn, pasta, or salads to add a savory taste and boost B vitamin intake.
When using baker’s yeast or nutritional yeast as a source of B vitamins, it’s important to remember that excessive intake of some B vitamins can lead to health problems. It’s always best to consult with a healthcare professional before adding large amounts of any supplement or food source to your diet.
Excessive intake of some B vitamins can lead to health problems. While B vitamins are water-soluble, meaning they are not stored in the body and any excess is typically excreted through urine, consuming large amounts can still cause adverse effects. Some potential issues related to excessive intake of specific B vitamins include:
- B1 (Thiamine): Excessive intake is rare, but high doses may cause digestive problems, rapid heartbeat, or skin flushing.
- B2 (Riboflavin): High doses can cause diarrhea, abdominal cramps, or an increased risk of kidney stones in susceptible individuals.
- B3 (Niacin): Excessive intake can cause flushing, liver damage, gout, and high blood sugar levels.
- B5 (Pantothenic acid): Very high doses may lead to diarrhea and digestive discomfort.
- B6 (Pyridoxine): Prolonged excessive intake can lead to nerve damage, causing numbness and tingling in the extremities.
- B7 (Biotin): Excessive intake is rare, but it may cause an imbalance in other B vitamins, leading to deficiencies.
- B9 (Folate): High doses can mask a vitamin B12 deficiency, which can lead to neurological damage if left untreated. Excessive intake may also increase the risk of certain types of cancer.
- B12 (Cobalamin): Although toxicity from excessive intake is rare, high doses may cause dizziness, headache, anxiety, or nausea.
Methylcobalamin is a form of vitamin B12 that is considered more bioavailable and easily absorbed by the body. Although generally safe when taken in appropriate doses, some people may experience side effects from methylcobalamin. These side effects are usually mild and may include:
- Headache
- Dizziness or lightheadedness
- Nausea or upset stomach
- Diarrhea
- Itching or rash
- Swelling, pain, or redness at the injection site (if administered by injection)
In rare cases, more serious side effects may occur, such as:
- An allergic reaction, characterized by difficulty breathing, swelling of the face, lips, tongue, or throat, and severe dizziness
- Rapid heartbeat or palpitations
- Muscle weakness or cramps
- Numbness or tingling in the extremities
It’s essential to follow the recommended daily allowance (RDA) for each B vitamin to avoid potential health problems or better use only natural sources such as yeast and bee pollen!
N-Acetyl L-Cysteine (NAC)
NAC is a very powerful anti-oxidant and assist the immune system in clearing toxicity.
N-Acetyl L-Cysteine (NAC) is a derivative of the amino acid cysteine, and it is a precursor to glutathione, an important antioxidant in the body. The mechanism of NAC is primarily related to its ability to increase glutathione levels, which helps to protect cells from oxidative stress and other harmful effects.
Specifically, NAC is believed to work by increasing the availability of cysteine, which is a key component of glutathione. Glutathione acts as a scavenger for reactive oxygen species (ROS) and other harmful molecules in the body, neutralizing them and preventing damage to cells and tissues.
In addition to its role in increasing glutathione levels, NAC has also been shown to have other effects on the body. For example, it has been found to have anti-inflammatory properties, and it may also help to modulate the immune system.
- De Rosa SC, Zaretsky MD, Dubs JG, et al. N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest. 2000;30(10):915-929. doi: 10.1046/j.1365-2362.2000.00742.x
This study investigated the effect of NAC supplementation on glutathione levels in HIV-infected individuals, who often have depleted glutathione levels due to increased oxidative stress. The results showed that NAC supplementation significantly increased glutathione levels in these individuals, indicating that NAC can help to replenish glutathione levels in conditions of oxidative stress.
- Samuni Y, Goldstein S, Dean OM, Berk M. The chemistry and biological activities of N-acetylcysteine. Biochim Biophys Acta Gen Subj. 2013;1830(8):4117-4129. doi: 10.1016/j.bbagen.2013.04.016
This review article provides an overview of the mechanism of action of NAC, including its ability to increase glutathione levels. The authors explain that NAC can be converted to cysteine in the body, which is then used to synthesize glutathione. They also note that NAC has been shown to increase the expression of genes involved in glutathione synthesis, further supporting its role in increasing glutathione levels.
- Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA. N-Acetylcysteine–a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007;7(4):355-359. doi: 10.1016/j.coph.2007.04.005
This review article discusses the potential therapeutic uses of NAC, including its role in increasing glutathione levels. The authors explain that NAC can provide a source of cysteine for glutathione synthesis, and that it can also increase the activity of enzymes involved in glutathione synthesis. They also note that NAC can scavenge free radicals directly, providing additional protection against oxidative stress.
Here is another suggested mechanism of NAC. Note that lipid peroxidation is discussed in detail here. Essentially NAC is very powerfull in preventing runaway lipid oxidation.
Overall, these studies suggest that NAC can increase glutathione levels in the body through a variety of mechanisms, including providing a source of cysteine for glutathione synthesis and increasing the activity of enzymes involved in glutathione synthesis.
Vitamin C, Glutathione, Lutein and redox potentials
Yes, Vitamin C, also known as ascorbic acid, is an essential nutrient with several important functions in the human body. But how much can it really do? One of its major benefits of ascorbic acid it’s water-solubility. Here are some of the key functions of Vitamin C:
1. Antioxidant Activity: Vitamin C is a potent antioxidant that helps protect cells from damage caused by free radicals, which are harmful molecules generated during normal cell metabolism or in response to environmental stressors like tobacco smoke and radiation. By neutralizing free radicals, Vitamin C helps prevent oxidative stress, which is linked to numerous health conditions, including aging and chronic diseases.
2. Collagen Synthesis: One of the most crucial functions of Vitamin C is its role in the synthesis of collagen, a key structural protein found in skin, blood vessels, tendons, ligaments, and bones. Vitamin C is necessary for the hydroxylation of collagen molecules, which stabilizes and strengthens the collagen.
3. Immune Function: Vitamin C enhances the immune system. It stimulates the production and function of white blood cells, especially neutrophils, lymphocytes, and phagocytes. It also helps these cells move more quickly to sites of infection and enhances their ability to consume and destroy microbes.
4. Nutrient Absorption: Vitamin C improves the absorption of non-heme iron (the type of iron present in plant-based foods), which is crucial for preventing iron deficiency and anemia. It reduces iron from its ferric to ferrous state, making it more soluble and easier to absorb in the intestine.
5. Wound Healing: Due to its role in collagen formation, Vitamin C is also essential for wound healing. Proper wound repair requires collagen production, and a deficiency in Vitamin C can lead to delayed healing.
6. Neurotransmitter Synthesis: Vitamin C is involved in the synthesis of several important neurotransmitters, including norepinephrine and serotonin, which are vital for mood regulation and brain function.
7. Protects Against Cardiovascular Disease: Vitamin C may help lower the risk of heart disease by reducing blood pressure, decreasing the stiffness of arteries, and improving other cardiovascular markers.
A table listing some Vitamin C-rich foods, including sauerkraut. The Vitamin C content is approximate and can vary based on factors like food preparation, cooking methods, and specific varieties. The values are provided per 100 grams (3.5 ounces) of each food item:
Food Item | Vitamin C Content (mg per 100g) |
---|---|
Red Bell Pepper | 128 – 190 |
Guava | 228 |
Kiwi | 93 |
Strawberries | 59 |
Oranges | 53 |
Papayas | 61 |
Broccoli | 89 |
Brussels Sprouts | 85 |
Kale | 120 |
Parsley | 133 |
Pineapple | 48 |
Mango | 36 |
Lemon | 53 |
Cauliflower | 48 |
Sauerkraut (fermented cabbage) | 19 |
Spinach | 28 |
Note:
- Sauerkraut: The Vitamin C content in sauerkraut can vary depending on the fermentation process and duration. Fermentation can actually increase the bioavailability of Vitamin C.
- Freshness and Cooking: Vitamin C is sensitive to light, heat, and air. Fresh, raw fruits and vegetables generally have the highest content. Cooking, especially boiling, can significantly reduce Vitamin C content in foods
It’s important to note that the human body cannot produce Vitamin C, so it must be obtained from the diet. Citrus fruits, strawberries, kiwi, bell peppers, broccoli, kale, and spinach are excellent sources of Vitamin C. While Vitamin C deficiency is relatively rare in developed countries, it can lead to scurvy, a disease characterized by anemia, weakness, gum disease, and skin problems. Regular consumption of Vitamin C-rich foods or supplements is necessary to maintain adequate levels in the body and support these essential functions.
Vitamin C (ascorbic acid) cannot pass freely through cell membranes because it is water-soluble. However, the body also uses special transport proteins to actively move vitamin C from the digestive tract into the bloodstream, and from the bloodstream into cells. These transport proteins, called sodium-dependent vitamin C transporters (SVCTs), help to regulate the amount of vitamin C in different tissues and ensure that it gets to where it is needed.
Without these transporters, vitamin C absorption and distribution throughout the body would be less efficient, and certain cells might not get enough of this important nutrient. Additionally, these transporters help to maintain vitamin C concentrations within cells, even when the concentration of vitamin C in the blood fluctuates.
Again, cell membranes are made up of a lipid bilayer that is hydrophobic (water-repelling). Water-soluble substances typically cannot easily cross this lipid barrier. Here’s how Vitamin C gets into cells:
- Transport Proteins: The uptake of ascorbic acid into cells is primarily facilitated by specific transport proteins. These are known as sodium-dependent Vitamin C transporters (SVCTs). SVCTs actively transport ascorbic acid into cells using the gradient of sodium ions. There are two types of SVCTs – SVCT1 and SVCT2. SVCT1 is primarily responsible for the absorption of vitamin C in the intestines and its reabsorption in the kidneys, which helps to prevent the loss of vitamin C in urine. SVCT2, on the other hand, is found in almost all body tissues and is responsible for transporting vitamin C into cells where it is needed.
- Dehydroascorbic Acid Uptake: Interestingly, dehydroascorbic acid (DHA), the oxidized form of Vitamin C, can be more readily transported across the cell membrane because it is structurally similar to glucose. Cells have glucose transporters (such as GLUT1 and GLUT3) that can mistakenly transport DHA into the cell. Once inside the cell, DHA can be reduced back to ascorbic acid.
- Limited by Concentration Gradient: The transport of Vitamin C into cells is not just passive diffusion but is regulated and dependent on the concentration gradient and the availability of transporters.
- Role of Kidneys in Regulation: The kidneys play a key role in regulating the level of Vitamin C in the body. They can reabsorb Vitamin C from urine or excrete it, depending on the body’s needs.
In summary, while Vitamin C’s water solubility is essential for its role in bodily fluids, its passage through cell membranes relies on specific transport mechanisms rather than passive diffusion through the lipid bilayer of cell membranes.
That said, it is important to note that consuming excessively high doses of vitamin C (such as those found in supplements) can saturate the SVCTs and result in unabsorbed vitamin C being excreted in the urine and can cause bowel problems. This is why it is not necessarily better to overdose on ascorbic acid and side effects in the bowel can be severe however short lived.
What is liposomal Vitamin C
Liposomal Vitamin C involves a unique method of delivering Vitamin C (ascorbic acid) to the body. This method encapsulates Vitamin C in liposomes, which are tiny, fat-like particles created from phospholipids, similar to the material that makes up our cell membranes. The idea behind liposomal encapsulation technology (LET) is to improve the delivery and absorption of Vitamin C in the body.
It is estimated that 5-10 times more bioavailable (taken up by the body’s cells) compared to traditional vitamin C supplements. Therefore ‘bowel tollerance’ may already be reached at 1000mg!
Here’s how liposomal Vitamin C works:
1. Improved Absorption: Normally, the absorption of Vitamin C in the gastrointestinal tract can be limited by several factors, such as intestinal absorption capacity and the presence of other competing substances. Liposomal Vitamin C is designed to bypass these limitations. The liposomal encapsulation helps protect Vitamin C from being broken down in the digestive tract and facilitates easier entry into the bloodstream.
2. Cell Membrane Fusion: Because the liposomes are made of a phospholipid bilayer similar to human cell membranes, they can merge more easily with cell membranes. This fusion allows the encapsulated Vitamin C to be directly delivered into the cells, increasing the cellular uptake of Vitamin C.
3. Reduced Gastrointestinal Distress: High doses of traditional Vitamin C supplements can sometimes cause gastrointestinal issues like diarrhea or stomach cramps. Since liposomal Vitamin C is absorbed more efficiently and enters the cells directly, it can often be taken in higher doses without the same gastrointestinal side effects.
4. Sustained Release: The encapsulation can also provide a sustained release of Vitamin C, maintaining its levels in the bloodstream for a longer period compared to traditional Vitamin C supplements.
5. Protection from Degradation: The liposomal encapsulation protects Vitamin C from oxidation and degradation that can occur in the digestive tract, ensuring that a higher proportion of the nutrient is intact and biologically available when it reaches the cells.
It’s important to note that while liposomal Vitamin C is often claimed to be superior in terms of absorption and effectiveness, scientific research validating these claims is still evolving. Some studies suggest that liposomal formulations may indeed offer enhanced bioavailability, but more extensive and rigorous research is needed to fully understand the benefits and effectiveness of this form of Vitamin C supplementation compared to traditional forms.
Vitamin C, or ascorbic acid, can cause diarrhea when taken in high doses, typically well above the Recommended Dietary Allowance (RDA). This effect is largely due to the osmotic activity of unabsorbed vitamin C in the gastrointestinal tract. Here’s a more detailed explanation:
- Osmotic Effect: Vitamin C is water-soluble, and when taken in high doses, it is not completely absorbed in the small intestine. The unabsorbed vitamin C continues into the colon, where it exerts an osmotic effect. This means it attracts water into the colon, increasing the water content of the stool.
- Increased Gastrointestinal Motility: High levels of vitamin C can also speed up the movement of the bowel (peristalsis). This rapid transit can decrease the time for water absorption in the colon, contributing to loose stools or diarrhea.
- Individual Tolerance Levels: The threshold for vitamin C causing diarrhea can vary significantly from person to person. Some individuals may experience gastrointestinal disturbances at doses as low as 1,000 mg (1 gram) per day, while others might tolerate much higher doses without any issues.
- Bowel Tolerance: The concept of “bowel tolerance” is often mentioned in discussions about vitamin C supplementation. This refers to the maximum dose of vitamin C a person can take without causing loose stools or diarrhea. It can vary depending on the individual and their current health status (for instance, during illness, the bowel tolerance for vitamin C can increase).
- Ascorbate Flush: Some protocols for determining an individual’s vitamin C requirement involve increasing the dose until diarrhea occurs (ascorbate flush) and then reducing the dose to just below that level. However, this method should be approached with caution and ideally under the guidance of a healthcare professional.
It’s important to note that the RDA for vitamin C for adults is 75 mg per day for women and 90 mg per day for men, with an upper limit set at 2,000 mg per day to prevent gastrointestinal disturbances and other potential side effects. High-dose vitamin C supplementation should be undertaken with a clear understanding of the potential risks and benefits, and ideally under medical supervision, particularly in the case of individuals with pre-existing health conditions or those taking certain medications. As with any supplement, it’s advisable to consult with a healthcare provider before starting liposomal Vitamin C, especially if you have underlying health conditions or are taking other medications.
Here’s how liposomal encapsulation works and why it’s beneficial:
- Creation of Liposomes: Liposomes are created in a laboratory setting. The process typically involves the dispersion of phospholipids in water. When these phospholipids are hydrated, they spontaneously form a bilayer structure, similar to that of cell membranes, with an aqueous interior. This bilayer can encapsulate both water-soluble and fat-soluble compounds.
- Encapsulation of Active Ingredients: The substance to be delivered (like a vitamin, drug, or nutrient) is trapped inside the liposome or within its lipid bilayer. This encapsulation can protect the active ingredient from degradation in the digestive system when ingested.
- Improved Absorption and Bioavailability: One of the primary advantages of liposomal encapsulation is improved bioavailability. The liposomal bilayer can merge with cell membranes, facilitating the delivery of the encapsulated substance directly into the cells. This process bypasses the need for the active ingredient to navigate the harsh environment of the digestive tract and the selective nature of the intestinal absorption barrier.
- Protection from Degradation: Many substances, particularly certain vitamins and medications, are susceptible to degradation in the presence of digestive enzymes and stomach acid. Liposomal encapsulation protects these substances, allowing them to reach the bloodstream and cells in a more intact form.
- Targeted Delivery: Research in liposomal technology is exploring the potential for targeted delivery of substances to specific tissues or organs. By manipulating the size, charge, and composition of the liposome, it’s possible to influence where liposomes are distributed in the body.
- Extended Circulation Time: Liposomes can also extend the circulation time of a drug or nutrient in the bloodstream, providing a more sustained release than traditional forms.
Liposomal Encapsulation Technology is used in a variety of applications, from enhancing the effectiveness of nutritional supplements (like Vitamin C and curcumin) to delivering chemotherapeutic drugs in cancer treatment. The technology continues to evolve, with ongoing research into improving its efficiency and exploring new applications in medicine and nutrition.
Liposomal technology works for many applications: Meligy 2023: liposomal encapsulation, as a novel carrier, for essential oils (LEOs) on growth, digestibility, intestinal microbiota, and bacterial metabolites of broiler chickens.
Chen 2023: Transmission electron microscopy (TEM) images: (a) liposomal vitamin C with an average diameter near 200 nm; (b) liposomal vitamin D3 with an average diameter near 100 nm. Samples of bilayer (unilamellar) vesicles are indicated by a red square.
How stable is Vitamin C?
Here’s what happens when ascorbic acid gets oxidized:
- Chemical Transformation: Ascorbic acid can be oxidized to dehydroascorbic acid. This reaction can happen through various processes, including exposure to oxygen, high temperatures, or certain enzymatic reactions in the body.
- Maintaining Functionality: The interesting aspect of this oxidation process is that dehydroascorbic acid retains the vitamin activity of ascorbic acid. The body can convert DHA back into ascorbic acid, thus preserving the vitamin’s functionality. This reversible transformation is a part of the normal metabolic processes of Vitamin C in the body.
- Antioxidant Properties: One of the roles of ascorbic acid in the body is to act as an antioxidant, protecting cells from oxidative damage by neutralizing free radicals. In the process of neutralizing free radicals, ascorbic acid itself becomes oxidized to DHA. This is part of the normal function of ascorbic acid as a sacrificial antioxidant – it is oxidized so that other structures in the cell can be protected.
- Limit of Reversibility: While the body can recycle DHA back into ascorbic acid, this process has limits. If DHA is not promptly reduced back to ascorbic acid, it can undergo irreversible degradation and lose its vitamin activity.
- Factors Influencing Oxidation: In the context of food storage and processing, several factors can accelerate the oxidation of ascorbic acid, including exposure to light, heat, air, and the presence of heavy metals or certain enzymes. This is why Vitamin C content in foods can decrease significantly during processing, storage, or cooking.
In summary, oxidation is a natural part of the life cycle of ascorbic acid in the body and in foods. While this process can temporarily change the form of Vitamin C to dehydroascorbic acid, the body has mechanisms to recycle it back to its active form, thereby maintaining its essential functions. However, excessive or prolonged oxidation, especially outside the body, can lead to a decrease in the effective Vitamin C content.
What are all the different players in buffering Reactive Oxygen species?
Redox potential refers to the tendency of a chemical species to acquire electrons and thereby be reduced. This property is important in biology and chemistry because it determines the direction and extent to which redox reactions occur.
Glutathione is a powerful antioxidant produced naturally by the body. However, under certain circumstances, such as illness, stress, or aging, the body’s demand for glutathione may exceed its capacity to produce it. In such cases, it may be beneficial to supplement glutathione.
However, glutathione taken orally is not well absorbed by the body. Most of it is broken down in the gut before it can reach the bloodstream. Therefore, to ensure that it gets directly into the bloodstream and can be distributed throughout the body, glutathione is often administered intravenously (IV). This method bypasses the digestive system, allowing for maximal absorption.
Glutathione, often abbreviated as GSH, is a powerful antioxidant produced in cells. It’s comprised largely of three amino acids: glutamine, glycine, and cysteine. Glutathione levels in the body may be reduced by a number of factors, including poor nutrition, environmental toxins, and stress. Its levels also decline with age.
Because of its high electron-donating power and its abundance in cells, glutathione maintains a reduced environment within cells. This means that it can donate electrons to unstable molecules (also called free radicals) that might otherwise react with important cellular components, such as DNA or cell membranes, causing damage.
Natural antioxidants, such as those found in fruits and vegetables, are also important in the body’s defenses against free radicals. These antioxidants work in different ways and in different locations within cells than glutathione, but they can also help to maintain the redox balance within cells.
The redox potential of a compound is typically measured in relation to the standard hydrogen electrode (SHE), which is arbitrarily given a potential of 0 volts. The redox potential of glutathione depends on the pH and the ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG), but it is generally around -240 mV.
The redox potentials of other natural antioxidants vary widely, depending on their structure and the specific chemical reaction they participate in. As a general rule, antioxidants must have a lower (more negative) redox potential than the radicals they are protecting against in order to be effective.
The Process of quenching oxidative species:
- ROS: Reactive oxygen species, like free radicals, are highly reactive and can cause cellular damage. They have an unpaired electron and are looking for an electron to stabilize.
- GSH (Reduced Glutathione): Glutathione in its reduced state is a powerful antioxidant. It has extra electrons it can donate to neutralize free radicals.
- Interaction: When a ROS interacts with GSH, the ROS takes an electron from GSH, which neutralizes the ROS and prevents it from causing damage.
- GSSG (Oxidized Glutathione): After donating an electron, GSH becomes oxidized glutathione (GSSG).
- Regeneration: With the help of an enzyme called glutathione reductase and NADPH (another molecule involved in redox reactions), GSSG is converted back to GSH, ready to donate another electron.
What else does Vitamin C do?
Vitamin C is generally considered safe for most people, but it can interact with some medications.
Specifically, Vitamin C may interact with certain immunosuppressive drugs by potentially enhancing the immune system, which might interfere with the action of these drugs. Some of these immunosuppressants include:
- Cyclosporine: High doses of vitamin C might decrease the effectiveness of cyclosporine, an immunosuppressant often used to prevent organ rejection after transplant surgery.
- Chemotherapy drugs: Vitamin C might interfere with some drugs used in chemotherapy by reducing their effectiveness.
These are just a few examples, and there may be other immunosuppressive drugs that could potentially interact with Vitamin C. It’s also important to remember that even though Vitamin C is a natural supplement, it can still have side effects and interact with medications. Therefore, anyone taking immunosuppressive drugs should discuss the use of Vitamin C or any other supplements with their healthcare provider to ensure safety.
In summary, Vitamin C is a vital nutrient that plays many roles in supporting immune function but it has rather low potential in buffering ROS.
- Antioxidant: Vitamin C acts as a powerful antioxidant, protecting important biomolecules like proteins, lipids, carbohydrates, and nucleic acids (DNA and RNA) from damage by free radicals and reactive oxygen species that are generated during normal metabolism and cell function, as well as through exposure to toxins and pollutants.
- Boosts Production of White Blood Cells: Vitamin C helps stimulate the production and function of white blood cells, including neutrophils, lymphocytes, and phagocytes, which play crucial roles in the immune response. Neutrophils are the first cells to reach the site of an infection, and Vitamin C helps these cells function more effectively while protecting them from damage by free radicals.
- Enhances Chemotaxis: Chemotaxis is the movement of immune cells towards the site of an infection or inflammation following a gradient of increasing concentration of certain molecules. Vitamin C enhances the chemotactic responses of neutrophils.
- Supports Barrier Function: Vitamin C contributes to maintaining the integrity of the skin and mucous membranes – the body’s primary physical barrier against pathogens.
- Supports Cellular Immunity: Vitamin C enhances the proliferation and differentiation of T- and B-lymphocytes, important cells of the immune system. It also has a role in the production of important signaling molecules like cytokines that help modulate the immune response.
- Modulates Inflammation: Vitamin C also helps to regulate the body’s inflammatory response, which is crucial for effectively fighting off infections but can be harmful if left unchecked.
In summary, vitamin C contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system. Deficiency in this nutrient can result in a reduced resistance against certain pathogens, while a sufficient intake can enhance various immune functions. It’s important to note that while taking vitamin C can support normal immune function, it is not absorbed unless your cell membrane has functional omega3 and supports the vitamin C receptors.
alpha-lipoic acid
Alpha-lipoic acid (ALA – not to be confused with alpha-Linolenic acid) is an antioxidant that’s found in foods such as spinach, broccoli, and potatoes. It’s also available as a dietary supplement and is produced in the body. Alpha-lipoic acid has been researched for various medical conditions, including diabetic neuropathy and other kinds of nerve-related conditions, as well as for general antioxidant support.
A “low” level of alpha-lipoic acid is not typically a standard medical diagnosis because it’s not routinely measured in clinical settings. However, insufficient amounts could potentially result in less effective cellular protection from oxidative stress.
Potential Consequences of Low Alpha-Lipoic Acid Levels:**
1. Oxidative Stress: A lack of antioxidants like ALA could make the body more susceptible to oxidative stress, which is implicated in aging and various diseases.
2. Reduced Energy Metabolism: ALA plays a role in energy production within cells, and low levels could hypothetically affect this process.
3. Neuropathy: There is some evidence that ALA may help with diabetic neuropathy, so low levels could potentially be of concern for individuals with this condition.
4. Immune System: Reduced levels of antioxidants may compromise the immune system, although this would also depend on other factors like the levels of other antioxidants in the body.
5. General Health: Antioxidants like ALA are thought to be beneficial for general well-being, although the specific benefits and requirements are still not fully understood.
If you are concerned about low levels of alpha-lipoic acid, it’s essential to consult with a healthcare provider for accurate diagnosis and appropriate treatment. Taking too much ALA as a supplement can also have risks, such as potential for hypoglycemia (low blood sugar) in diabetics or interactions with other medications.
There isn’t a standardized test to measure alpha-lipoic acid levels, so if you’re concerned about having low levels, consult a healthcare provider for personalized advice, which might include dietary changes or supplementation.
The human body does indeed produce alpha-lipoic acid (ALA) naturally, but in small amounts. It’s considered a “conditionally essential” nutrient, meaning that under most normal circumstances, the body can synthesize enough ALA to meet its basic needs. However, in certain situations—like with age, stress, or illness—the body’s ability to produce or utilize ALA might be compromised, and dietary intake or supplementation could become more important.
ALA is involved in energy metabolism and acts as an antioxidant, neutralizing harmful free radicals in the body. In addition to endogenous production (meaning it’s made by the body), ALA can also be obtained through the diet or as a supplement. Foods like red meat, organ meats, and certain vegetables like spinach and broccoli contain ALA, though the amounts are generally much lower than what is available through supplementation.
So to clarify: Yes, the body does produce alpha-lipoic acid, but you can also get it from your diet or supplements.
Alpha-lipoic acid (ALA) serves as a cofactor for some enzyme complexes in the mitochondria that are part of the citric acid cycle, also known as the tricarboxylic acid (TCA) cycle or Krebs cycle. However, it’s worth noting that ALA is not a direct participant or critical cofactor in the core reactions of the citric acid cycle itself, such as those involving enzymes like citrate synthase, aconitase, or succinate dehydrogenase.
ALA acts more as an antioxidant and a cofactor in other mitochondrial enzyme complexes involved in energy metabolism. It has the unique ability to regenerate other antioxidants like vitamin C, vitamin E, and glutathione, enhancing the body’s overall antioxidant defense system.
In its role as a cofactor, ALA helps with the decarboxylation of alpha-keto acids, like pyruvate and alpha-ketoglutarate, which are part of the metabolic pathways connected to the TCA cycle. These reactions are essential for the body’s energy production but are separate from the core enzymes of the TCA cycle itself.
It’s not clear if ALA can be substituted entirely, as it has unique properties, especially its ability to work both as a water-soluble and fat-soluble antioxidant. In most cases, the body produces enough ALA to fulfill its roles, and deficiency is rare. However, ALA supplements are available and are used for various purposes, such as managing diabetic neuropathy and acting as a general antioxidant.
So, while ALA plays a role in energy metabolism and acts as a cofactor for some enzyme complexes, it is not a core component of the citric acid cycle itself. If you’re concerned about nutrient deficiencies give us a call.
Curcumin
Curcumin is a bioactive compound found in turmeric, a spice commonly used in Asian cuisine. It has been widely studied for its anti-inflammatory, antioxidant, and neuroprotective properties. Here’s how curcumin may impact nerves and neurological health:
- Anti-inflammatory Effects: Curcumin is known for its potent anti-inflammatory properties. Chronic inflammation is a contributing factor in many neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. By reducing inflammation, curcumin may help protect nerve cells from damage.
- Antioxidant Properties: Curcumin is a powerful antioxidant that can neutralize free radicals, which are harmful molecules that can damage cells, including nerve cells. By protecting cells from oxidative stress, curcumin may help maintain the integrity of neurons and support overall brain health.
- Neuroprotection: Curcumin has been shown to promote the production of brain-derived neurotrophic factor (BDNF), a protein that plays a crucial role in the growth, maintenance, and survival of neurons. Increased levels of BDNF can support brain plasticity and cognitive function.
- Potential in Treating Neurodegenerative Diseases: Due to its anti-inflammatory and antioxidant effects, curcumin has been studied as a potential therapeutic agent in the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Some research suggests that curcumin may help reduce the formation of amyloid plaques and tau tangles, which are characteristic of Alzheimer’s disease.
- Pain Relief: Curcumin may also have a role in managing neuropathic pain, a type of pain caused by damage to the nervous system. Its anti-inflammatory properties can help reduce pain and discomfort associated with conditions like diabetic neuropathy.
While curcumin has shown promise in various studies, it’s important to note that its bioavailability (the rate and extent to which it is absorbed and used by the body) is relatively low. Therefore, it is often combined with other substances, such as piperine (found in black pepper), to enhance its absorption.
Vitamin E and CoQ10
Vitamin E and Coenzyme Q10 (CoQ10) are both known for their powerful antioxidant properties, which largely stem from their redox potential. Here’s a quick overview of how they work:
- Vitamin E: Vitamin E, in its active form alpha-tocopherol, is a lipid-soluble antioxidant. It resides mostly in cell membranes where it prevents the propagation of reactive oxygen species (ROS), especially lipid peroxides, by donating a hydrogen atom (thus becoming a tocopheroxyl radical). This “sacrificial” activity enables it to stop the chain reaction of lipid peroxidation, protecting the cell membrane from oxidative damage. The tocopheroxyl radical can then be reduced back to tocopherol by vitamin C, restoring its antioxidant potential.
- Coenzyme Q10: CoQ10, also known as ubiquinone (oxidized form) and ubiquinol (reduced form), is a lipid-soluble antioxidant primarily found in mitochondria. Its redox potential lies in its ability to accept and donate electrons during energy production. In the process, it can neutralize free radicals and reduce oxidative stress. As an antioxidant, the ubiquinol form can donate an electron, turning into ubiquinone, and this process can be reversed when ubiquinone is reduced back to ubiquinol.
Vitamin E is a potent antioxidant that is important for the proper functioning of the immune system. It plays several roles in supporting immune health:
- Antioxidant Role: Vitamin E is a fat-soluble antioxidant that helps protect cell membranes from damage by reactive oxygen species and free radicals. This protective effect is particularly important for immune cells, such as phagocytes and lymphocytes, as they generate reactive oxygen species as part of the immune response.
- Enhances Cell-Mediated Immunity: Vitamin E is known to enhance cell-mediated immunity, which is particularly important in defense against intracellular pathogens, cancer cells, and in tissue repair. The mechanism is thought to involve a variety of actions, including enhancing the function of T cells (a type of white blood cell that plays a central role in cell-mediated immunity).
- Modulates Inflammatory Response: Vitamin E may modulate the body’s inflammatory response, helping to balance the immune response and prevent excessive inflammation.
- Supports Aging Immune System: Vitamin E supplementation has been shown to improve immune responses in the elderly, who often have reduced immune function due to aging. It helps maintain the integrity and function of the immune cells in these individuals, helping them resist infections more effectively.
Both of these molecules are crucial in maintaining the redox balance within cells, and supplementation with these antioxidants is sometimes recommended in conditions characterized by oxidative stress. However, the decision to supplement should always be made in consultation with a healthcare provider, as individual needs can vary widely, and there can be risks associated with excessive intake.
- Vitamin E: Absorption of vitamin E in the gut is influenced by various factors such as the presence of dietary fat, pancreatic function, and integrity of the gut wall. After ingestion, vitamin E is incorporated into micelles in the small intestine and then absorbed into enterocytes (intestinal cells) by passive diffusion. Once inside, it’s incorporated into chylomicrons, which are lipoprotein particles that transport dietary lipids from the intestines to other locations in the body. There is no specific receptor for vitamin E absorption in the gut.
- Coenzyme Q10 (CoQ10): CoQ10 is a fat-soluble compound, and its absorption is also enhanced in the presence of dietary fat. Similar to vitamin E, CoQ10 is absorbed via passive diffusion across the enterocyte cell membrane in the small intestine. After absorption, CoQ10 is incorporated into chylomicrons and then enters systemic circulation. Again, no specific receptor is known for CoQ10 absorption in the gut.
Both vitamin E and CoQ10 absorption can be relatively inefficient, and their bioavailability can vary based on factors such as the form in which they’re taken (e.g., softgels, tablets), whether they’re taken with meals, and individual physiological differences. CoQ10, in particular, has been reported to have low bioavailability due to its poor water solubility and large molecular weight. Formulations with improved bioavailability, such as ubiquinol or those that include solubilizing agents, are available on the market.
Both Vitamin E and Coenzyme Q10 (CoQ10) are sensitive to oxidation, which means that under certain conditions, they can degrade or “turn rancid.” Here are some key points to consider:
- Vitamin E: As a fat-soluble antioxidant, Vitamin E’s primary role is to neutralize harmful free radicals in the body, which can result in its own oxidation. However, this is a normal part of its function and doesn’t equate to it becoming rancid. But if Vitamin E supplements are exposed to excessive heat, light, or air, they can oxidize and lose their potency. This is why it’s recommended to store Vitamin E supplements in a cool, dark place and to use them before the expiration date.
- Coenzyme Q10: CoQ10 is also a fat-soluble compound and can be prone to oxidation if not stored properly. CoQ10 supplements should be stored in a cool, dark place to help preserve their integrity. When CoQ10 oxidizes, it can lose its potency.
To minimize the risk of oxidation, it’s important to store these supplements according to the manufacturer’s instructions, typically in a cool, dark place away from moisture. If a supplement changes color, develops an unusual odor, or the expiration date has passed, it’s best not to consume it.
There isn’t a simple at-home way to test if these supplements have turned rancid!
What about Liposomal Glutathione?
The issue with oral glutathione supplementation, in its traditional forms, is primarily related to its poor bioavailability. Glutathione is a tripeptide composed of three amino acids: cysteine, glutamic acid, and glycine. When taken orally, it can be broken down by enzymes in the gastrointestinal tract before it has a chance to be absorbed effectively, reducing its impact.
Here are the key points regarding the challenges of oral glutathione and the potential of liposomal forms:
1. Breakdown in the Gut: Oral glutathione faces the challenge of being broken down by stomach acids and enzymes. This degradation can significantly reduce the amount of intact glutathione available for absorption into the bloodstream.
2. Poor Absorption: Even if glutathione survives the digestive process, its absorption in the intestine can be limited, further reducing its bioavailability.
3. Liposomal Glutathione: Liposomal technology aims to overcome these barriers. In this form, glutathione is encapsulated within liposomes, which are tiny vesicles made of lipid bilayers. These liposomes can protect glutathione from the harsh environment of the digestive system and may enhance its absorption through the intestinal lining.
4. Research on Liposomal Glutathione: There has been growing interest in the use of liposomal glutathione, and some studies have suggested that it may offer better bioavailability than non-liposomal forms. For example, a study published in the “European Journal of Clinical Nutrition” in 2018 found that liposomal glutathione was effective in increasing body stores of glutathione in healthy adults.
5. Continued Research: While these findings are promising, the research in this area is still evolving. The number of studies is relatively limited, and further research is needed to comprehensively understand the effectiveness of liposomal glutathione, including its long-term effects and benefits for specific health conditions.
6. Safety and Efficacy: It’s also important to consider the safety and efficacy of liposomal supplements, as the quality and composition of liposomal products can vary significantly between manufacturers.
Liposomal glutathione is a form of glutathione, an important antioxidant in the body, packaged within liposomes to enhance its absorption. Glutathione plays a crucial role in reducing oxidative stress, detoxifying harmful substances, and supporting the immune system. However, when taken orally in traditional supplement forms, glutathione faces challenges in terms of bioavailability due to degradation in the gastrointestinal tract and limited absorption.
Liposomal glutathione is designed to address these issues:
1. Enhanced Absorption: Liposomes are small vesicles made of lipid bilayers, similar to cell membranes. Encapsulating glutathione in liposomes is thought to protect it from being broken down in the digestive tract and may facilitate its absorption into the bloodstream.
2. Cellular Uptake: Due to their composition, liposomes can merge with the cell membranes, potentially allowing for more direct cellular uptake of glutathione.
3. Reduced Breakdown: The liposomal encapsulation protects glutathione from the harsh environment of the gastrointestinal tract, which can break down and degrade non-encapsulated glutathione.
4. Potential Clinical Benefits: Some studies suggest that liposomal glutathione may have benefits in terms of increasing blood and cellular glutathione levels, reducing oxidative stress, and improving immune function. These effects could have implications for a variety of health conditions where oxidative stress and reduced antioxidant capacity are concerns.
Recent studies on the bioavailability of liposomal glutathione (GSH) have provided valuable insights. Here are some key findings:
1. Elevation of Glutathione Levels and Immune Function: A 1-month pilot clinical study involving healthy adults examined the effects of oral liposomal GSH at doses of 500 and 1000 mg per day. The study found significant elevations in GSH levels after one week, with maximum increases observed after two weeks. These increases were 40% in whole blood, 25% in erythrocytes, 28% in plasma, and 100% in peripheral blood mononuclear cells (PBMCs). Additionally, notable reductions in oxidative stress biomarkers and enhancements in immune function markers, such as Natural killer (NK) cell cytotoxicity and lymphocyte proliferation, were observed. These findings suggest the effectiveness of daily liposomal GSH administration in elevating GSH stores and impacting immune function and oxidative stress levels. https://pubmed.ncbi.nlm.nih.gov/28853742/
2. Liposomal vs. Sublingual Forms: Recent research indicates that GSH administration in liposomal or sublingual forms may offer better bioavailability and positively impact systemic GSH levels. This suggests that these forms might be more effective in bypassing gastrointestinal digestion, thus enhancing the absorption and effectiveness of GSH. https://pubmed.ncbi.nlm.nih.gov/37035339/
3. Randomized Controlled Trials: Another study, a 6-month randomized, double-blinded, placebo-controlled trial, aimed to determine the long-term effectiveness of oral GSH supplementation on body stores of GSH in healthy adults. The trial used doses of 250 or 1,000 mg/day of GSH and assessed levels in blood, erythrocytes, plasma, lymphocytes, and exfoliated buccal mucosal cells. This study contributes to understanding the longer-term impacts of GSH supplementation. https://pubmed.ncbi.nlm.nih.gov/24791752/
4. Comparative Study on Bioavailability: A study compared the bioavailability of a new sublingual form of GSH with two commonly used dietary supplements, N-acetylcysteine (NAC) and oral GSH. This research focused on the bioavailability, effects on oxidative stress markers, and safety of these supplements. Such comparative studies are crucial for determining the most effective and safe forms of GSH supplementation.
5. Study on Individuals with Type 2 Diabetes Mellitus (T2DM): A clinical trial examined the effects of oral liposomal glutathione supplementation in individuals with T2DM. The study reported that supplementation for 3 months reduced levels of oxidative stress in all blood components, highlighting the potential therapeutic effects of L-GSH supplementation in managing conditions like T2DM.
These studies collectively indicate the promising potential of liposomal glutathione in improving glutathione levels, reducing oxidative stress, and enhancing immune function, with implications for various health conditions, including oxidative stress-related diseases and diabetes management.
However, it’s important to note the following:
– Scientific Evidence: While the concept of liposomal glutathione is promising, and there is some supportive research, the scientific community still requires more comprehensive and rigorous studies to fully validate the efficacy and benefits of liposomal glutathione over non-liposomal forms.
– Quality and Composition: The effectiveness of liposomal glutathione can depend on the quality of the liposomal formulation, including factors like the size of the liposomes, the stability of the preparation, and the concentration of glutathione.
– Individual Variability: Responses to liposomal glutathione can vary based on individual health status, gut health, and other personal factors.
In summary, liposomal glutathione is a promising form of glutathione supplementation with potential advantages in terms of absorption and effectiveness, but further research is needed to fully establish its benefits and optimal use.
Lutein, beta carotene and Vitamin A
Lutein is a carotenoid vitamin, similar to vitamin A and beta carotene. It’s often referred to as the “eye vitamin” because it’s known to protect the eyes from damage caused by sunlight and oxidative stress.
Lutein is primarily found in green leafy vegetables such as spinach and kale, as well as other foods including eggs, citrus fruits, and even some animal fats.
A deficiency in lutein isn’t defined in the same way as with other vitamins, since the body doesn’t strictly require it for any vital functions. However, low levels of lutein in the diet have been associated with an increased risk of chronic eye diseases, including age-related macular degeneration (AMD) and cataracts.
Symptoms of a lutein deficiency may not be noticeable until an eye condition such as AMD begins to develop. These can include decreased visual acuity, issues with glare recovery, and in the case of AMD, central vision loss.
Maintaining a diet rich in lutein can support overall eye health and may decrease the risk of chronic eye diseases. Lutein supplements are also available, though you should always consult with a healthcare provider before starting any new supplement regimen.
One large egg yolk contains approximately 200-300 micrograms of lutein and zeaxanthin combined. Some studies suggest that an intake of about 6-10 mg of lutein per day may be beneficial for eye health, but this is not an officially recognized daily value. Therefore, if we take the upper limit of the estimate (300 micrograms or 0.3 milligrams), an egg yolk would contain only about 3-5% of this suggested amount.
A typical, large egg also contains approximately 80 micrograms of vitamin A, which is about 9% of the recommended daily intake for adult men and 11% for adult women. It’s important to note that vitamin A in eggs is primarily found in the yolk.
This amount can vary somewhat depending on the diet and overall health of the hen that laid the egg. For example, eggs from hens that are fed diets rich in certain nutrients can have higher levels of those nutrients.
Lutein is a carotenoid that is better absorbed in the presence of dietary fats, so the absorption can be improved when eggs are consumed as part of a meal that includes healthy fats.
Beta-carotene is converted to vitamin A (retinol) in the body, and it’s used in the formation of a specific protein in our eyes called rhodopsin, which is responsible for light absorption in retinal receptors.
The conversion rate of beta-carotene to retinol is highly variable, depending on a number of factors such as the food matrix, the individual’s metabolic rate, the amount consumed, and other dietary factors.
One study suggested that in humans, the conversion of beta-carotene to vitamin A is surprisingly low. About 12 units of dietary beta-carotene are needed to produce 1 unit of retinol (vitamin A).
So, it’s essential to consume foods rich in both beta-carotene and vitamin A. As vitamin A deficiency can lead to night blindness and even permanent blindness, it’s vital to ensure adequate intake of these nutrients.
Remember, it’s always recommended to obtain nutrients from food first and foremost, but in some cases, supplementation may be necessary. You should always consult with a healthcare provider for personalized advice.
The recommended dietary allowance (RDA) for vitamin A is 900 micrograms (mcg) per day for men and 700 mcg per day for women.
In summary, Beta-carotene is a type of carotenoid that can be converted into vitamin A in the body. Foods that are high in beta-carotene include:
- Carrots
- Sweet potatoes
- Spinach
- Kale
- Butternut squash
- Apricots
- Pumpkin
Vitamin A is a fat-soluble vitamin, which means it’s best absorbed when eaten with fat. Foods that are high in vitamin A include:
- Liver (beef, pork, chicken, turkey, fish)
- Fish oils
- Milk and eggs
- Provitamin A carotenoids from fruits and vegetables, including beta-carotene
Please remember that vitamin A is a fat-soluble vitamin, which means your body can store it. Consuming too much can lead to vitamin A toxicity, so it’s important not to exceed the recommended daily intake.
What can ozone treatments do for me?
Ozone (O3) is a strong oxidizing agent with a redox potential of 2.07 V, which makes it stronger than other common oxidants such as hydrogen peroxide or chlorine. In terms of biomedical applications, ozone therapy is a form of alternative medicine that purports to increase the amount of oxygen in the body through the introduction of ozone.
The use of ozone in medicine has been suggested to have several therapeutic effects. These include:
- Disinfection: Ozone has the ability to kill bacteria, viruses, and fungi, which can be useful in certain medical treatments.
- Stimulation of oxygen metabolism: Ozone has been suggested to stimulate the enzymes involved in oxygen metabolism, potentially improving the delivery of oxygen to cells and tissues.
- Modulation of the immune system: Some studies suggest that ozone can modulate the immune system, although the mechanisms are not entirely clear.
- Activation of the antioxidant system: Ozone has been suggested to activate the body’s antioxidant system, which can help neutralize harmful free radicals.
However, it’s important to note that while some studies have found potential benefits of ozone therapy, others have reported adverse effects, and its use remains controversial.
Hormesis is a biological phenomenon whereby a beneficial effect (improved health, stress tolerance, growth, or longevity) results from exposure to low doses of an agent or condition that is otherwise toxic or lethal when given at higher doses.
The concept of hormesis has been applied to a variety of interventions, including exercise, fasting, and exposure to cold, heat, radiation, and various natural and synthetic compounds.
Ozone therapy has been suggested to trigger a form of hormesis. By introducing a low-level oxidative stress with ozone, the body may potentially respond by upregulating its antioxidant defenses and possibly promoting cellular repair processes. Some proponents of ozone therapy believe that this can promote the health and function of various bodily systems, including the immune system and circulatory system.
Regarding stem cells, it’s important to note that the effect of ozone therapy on stem cells is not fully understood and the research is still in early stages. There’s some evidence from animal and in vitro studies suggesting that ozone therapy might influence the behavior of stem cells, but it’s unclear how these findings translate to humans. For instance, some research suggests that ozone could stimulate the mobilization of stem cells from the bone marrow, which might aid in tissue repair processes.
Mechanism:
Seyam 2018: An endogenous cascade is started when beginning the use of O3 therapy. In response, a stress is induced from the biologically active substrates that are released. Because of O3‘s ability to dissolve in the aqueous component of plasma, it can cause this oxidative stress.4 Hydrogen peroxide and a reactive species (ROS) are formed when O3 reacts with water and polyunsaturated fatty acids.
Vitamin K
Yes, vitamin K is important for bone health. Vitamin K plays a critical role in bone metabolism and helps to build strong bones by activating a protein called osteocalcin, which helps to incorporate calcium into the bone matrix. However the situation is complicated since its effects cannot be separated from Vitamin D3. Generally it is recommend to add vitamin K only to very large doses of Vitamin D3 (colecalciferol)
Here are some studies that support the benefits of vitamin K for bone health:
- Knapen, M. H., Schurgers, L. J., & Vermeer, C. (2007). Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporosis International, 18(7), 963-972. doi: 10.1007/s00198-007-0340-4
- Bolton-Smith, C., McMurdo, M. E., Paterson, C. R., Mole, P. A., & Harvey, J. M. (2007). Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women. Journal of Bone and Mineral Research, 22(4), 509-519. doi: 10.1359/jbmr.070116
- Booth, S. L., Tucker, K. L., Chen, H., Hannan, M. T., Gagnon, D. R., Cupples, L. A., & Kiel, D. P. (2000). Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. American Journal of Clinical Nutrition, 71(5), 1201-1208. doi: 10.1093/ajcn/71.5.1201
- Braam, L. A., Knapen, M. H., Geusens, P., Brouns, F., Hamulyak, K., Gerichhausen, M. J., & Vermeer, C. (2003). Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. Calcified Tissue International, 73(1), 21-26. doi: 10.1007/s00223-002-2081-1
In conclusion, vitamin K is important for bone health and may help to reduce the risk of fractures and osteoporosis. It is important to include foods that are rich in vitamin K, such as leafy greens, broccoli, and Brussels sprouts, in your diet, or to consider supplementation if needed.
Nattokinase
Natto, a traditional Japanese food made from fermented soybeans, is known for its distinctive strong flavor, sticky texture, and stringy consistency. It’s a staple in Japanese cuisine and is highly valued for its nutritional and health benefits especially as a ‘blood thinner’. Here are some of the key benefits of natto:
- Rich in Nutrients: Natto is an excellent source of protein, dietary fiber, vitamins (especially Vitamin K2), and minerals such as iron, calcium, magnesium, potassium, zinc, and selenium.
- High in Vitamin K2: Natto is one of the richest dietary sources of Vitamin K2 (menaquinone), which is crucial for bone health and cardiovascular health. Vitamin K2 helps direct calcium to the bones and teeth where it’s needed, and away from the arteries where it could cause harm.
- Contains Nattokinase: Natto contains an enzyme called nattokinase, which is believed to have blood-thinning and clot-dissolving properties. This could potentially be beneficial for cardiovascular health by reducing the risk of blood clots.
- Probiotic Properties: The fermentation process used to create natto produces beneficial bacteria, Bacillus subtilis natto, which can promote gut health. These probiotics can help balance the gut microbiome, aid in digestion, and support the immune system.
- Promotes Bone Health: The high levels of Vitamin K2 in natto are associated with improved bone health and a lower risk of osteoporosis. Vitamin K2 plays a role in bone metabolism and helps maintain bone mineral density.
- Cardiovascular Health: Some studies suggest that natto consumption may contribute to lower rates of cardiovascular disease, possibly due to the effects of nattokinase and Vitamin K2 on blood clotting and vascular health.
- Source of Isoflavones: Natto is a good source of isoflavones, plant compounds that can act as antioxidants and may have various health benefits, including potentially reducing the risk of certain cancers and alleviating menopausal symptoms.
- Enhanced Absorption of Nutrients: Fermented foods like natto can enhance the bioavailability of nutrients, making them more accessible for the body to use.
- Cholesterol Regulation: Some evidence suggests that natto consumption can help regulate cholesterol levels, possibly due to the fiber and probiotics it contains.
- Weight Management: High in protein and fiber, natto can be a satisfying food that may help with weight management as part of a balanced diet.
It’s important to note that natto’s unique flavor and texture may not be appealing to everyone, particularly if you’re not accustomed to fermented foods. In essence Natto can be prepared at home from soy and the Natto starter culture (Bacillus subtilis natto).
Nattokinase, an enzyme derived from natto, a traditional Japanese fermented soybean food, is known for its potential blood-thinning properties. Here’s how it works:
- Fibrinolysis: Nattokinase primarily assists in breaking down fibrin, a protein involved in blood clot formation. Fibrin is a key component of blood clots, providing them with structure and stability. Nattokinase enhances the body’s natural fibrinolytic activity, which is the process of breaking down fibrin clots. This action helps to keep the blood flowing smoothly and can prevent clots from becoming problematic.
- Plasmin Activation: Nattokinase may also increase the activity of plasmin, another enzyme that breaks down fibrin. It does this indirectly by inhibiting plasminogen activator inhibitor-1 (PAI-1), which is a natural inhibitor of plasmin. By reducing the activity of PAI-1, plasmin activity is enhanced, leading to increased breakdown of fibrin.
- Preventing Excessive Clotting: By aiding the breakdown of fibrin, nattokinase helps in preventing excessive clotting (thrombosis) and maintaining normal blood flow. This is particularly important in the arteries and veins, where blood clots can lead to conditions such as heart attacks, strokes, and deep vein thrombosis.
- Platelet Aggregation: There is some evidence that nattokinase may also help reduce platelet aggregation, which is the clumping together of platelets in the blood – another process that contributes to clot formation.
- Blood Viscosity: Nattokinase might also play a role in reducing blood viscosity, which can further aid in improving overall circulation and reducing the risk of clot formation.
It’s important to note that while nattokinase has potential benefits for cardiovascular health due to its blood-thinning properties, it should be used cautiously, especially in individuals who are already on anticoagulant (blood-thinning) medication, as it may increase the risk of bleeding. Always consult with a healthcare provider before starting any new supplement, including nattokinase, to ensure that it is safe and appropriate for your individual health needs.
Herbal Medicine
Chinese or Indian or Western herbs are very powerful medicines. They are NOT SUPPLEMENTS. They should be prescribed in specific formulas by a trained herbal practitioner. In combination with supplements they will address acute and chronic medical conditions or well being longevity. In addition, there is a significant difference in Chinese Herbs, which are based on a sophisticated diagnostic system rather than Western herbs that mostly based on treating symptoms.
The research of herbs is exploding however we still have very little understand of the biochemical ingredients and their interplay. A biochemical analyses of a single herb is complex however simple experiments such as these can shine light on their function.
As you can see this herb had profound effects on hypertension in this experiment on mice but also their fat/hormone metabolism. The combination of omega3 and Chinese Herbs is a very powerful faster approach to health problems as the effect of omega3 alone is slow and takes month.
Ahiflower
Rosemary extract
Not a traditional supplement but also not a typical “herb”. In general extracts are concentrated medicinals that form their own category.
Rosemary extract is known for its high antioxidant content, which contributes to its various health benefits and its use as a natural preservative in foods. The primary antioxidants in rosemary extract include:
- Carnosic Acid: This is one of the main active components in rosemary extract. Carnosic acid is a potent antioxidant that can protect cells and tissues from oxidative stress. It is often used in food preservation due to its ability to inhibit lipid peroxidation, thereby prolonging the shelf life of food products.
- Rosmarinic Acid: Another significant antioxidant in rosemary, rosmarinic acid has strong anti-inflammatory and antimicrobial properties. It’s also known for its ability to neutralize free radicals and has been studied for potential benefits in allergy treatments and other inflammatory conditions.
- Carnosol: This phenolic diterpene in rosemary has demonstrated antioxidant, anti-inflammatory, and anticarcinogenic properties. Carnosol contributes to rosemary’s ability to protect against oxidative damage.
- Ursolic Acid: While present in smaller amounts, ursolic acid in rosemary has been recognized for its antioxidant, anti-inflammatory, and anticancer activities. It’s also been studied for its potential in promoting muscle growth and reducing muscle atrophy.
- Flavonoids: Rosemary contains several flavonoids like genkwanin and hesperidin, which have antioxidant properties. Flavonoids are known for their ability to scavenge free radicals and protect against oxidative stress.
- Essential Oils: The essential oils in rosemary, including eucalyptol and camphor, also have antioxidant properties, although they are more recognized for their aromatic qualities.
- Vitamins and Minerals: While not as concentrated as the compounds listed above, rosemary also contains vitamins (like Vitamin C) and minerals that contribute to its overall antioxidant capacity.
The combination of these compounds makes rosemary extract a potent antioxidant source, widely used in both culinary and medicinal applications. Its antioxidants are linked to benefits like improved digestion, brain health, and potential protective effects against cancer and heart disease. Additionally, due to its natural preservative properties, rosemary extract is often used in the food industry to extend the shelf life of products by preventing oxidation.
Carnosic acid and rosmarinic acid, two potent antioxidants found in rosemary extract, have properties that can help protect fatty acids, including omega-3 fatty acids, from oxidative degradation (rancidity). Here’s how they can be beneficial in preserving omega-3 fats:
- Antioxidant Properties: Both carnosic and rosmarinic acids are strong antioxidants. Antioxidants work by neutralizing free radicals, which are unstable molecules that can cause oxidative damage to various components in food, including fats.
- Preventing Rancidity: Omega-3 fatty acids, which are polyunsaturated fats, are particularly prone to oxidation due to their chemical structure. When omega-3s oxidize, they become rancid, losing their nutritional value and potentially developing harmful compounds. The antioxidant action of carnosic and rosmarinic acids can help inhibit this oxidation process.
- Applications in Food Preservation: Rosemary extracts, rich in these antioxidants, are often used in the food industry as natural preservatives to extend the shelf life of products rich in unsaturated fats, like fish oils and other omega-3 supplements. They help maintain the quality and stability of these products by protecting against oxidative degradation.
- Synergistic Effects with Other Antioxidants: The protective effect of carnosic and rosmarinic acids can be enhanced when used in combination with other antioxidants, such as Vitamin E (tocopherols), which is also commonly used to stabilize omega-3 oils.
- Mechanism of Action: The mechanism by which these compounds exert their antioxidant effects includes scavenging free radicals, chelating metal ions that can catalyze oxidation, and breaking the chain reaction of lipid oxidation.
It’s important to note that while carnosic and rosmarinic acids can help reduce the oxidation of omega-3 fatty acids, their effectiveness depends on several factors, including the concentration of the antioxidants, the storage conditions of the product (like exposure to light, heat, and air), and the presence of other pro-oxidant factors.
In summary, carnosic and rosmarinic acids in rosemary extract are beneficial in protecting omega-3 fatty acids from oxidation, thus helping to preserve their quality and nutritional value in various food products and supplements. However the use of aromatic extracts needs to be treated with caution! Due to their potency they can have significant side effects.
While aromatic extracts like those from rosemary (containing compounds such as carnosic acid and rosmarinic acid) have beneficial properties, they should indeed be used with caution due to their potency and potential side effects. Here are some considerations to keep in mind:
- Concentration and Dosage: High concentrations of these extracts can be more potent and thus carry a higher risk of side effects. It’s important to use them in moderation and according to recommended dosages, whether in food, as a supplement, or in therapeutic applications.
- Allergic Reactions: Some individuals may be allergic or sensitive to specific compounds in aromatic extracts. Such reactions can range from mild skin irritation to more severe allergic responses.
- Interactions with Medications: Compounds in aromatic extracts can interact with certain medications, potentially altering their effects. For example, they may interfere with anticoagulants, antiplatelet agents, and certain anti-inflammatory drugs.
- Pregnancy and Breastfeeding: Pregnant and breastfeeding women should be particularly cautious with the use of herbal extracts, as certain compounds can affect fetal development or be passed to the infant through breast milk.
- Impact on Medical Conditions: Individuals with certain health conditions should be cautious. For instance, highly concentrated extracts can affect blood sugar levels, which is a concern for people with diabetes, or blood pressure, affecting those with hypertension.
- Quality and Purity: The quality and purity of herbal extracts can vary greatly depending on the source and method of extraction. Impurities or contaminants can pose additional health risks.
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Saffron
You will find Saffron added to many Zinzino products especially viva for its outstanding benefits. Saffron, derived from the dried stigmas of the Crocus sativus flower, is not only a highly prized spice but also has a variety of potential health benefits. Here are some of the notable benefits attributed to saffron:
- Mood Improvement: Saffron has been studied for its potential antidepressant properties. Some research suggests that it may help improve symptoms of depression by increasing serotonin levels in the brain.
- Antioxidant Properties: Saffron contains antioxidants such as crocin, crocetin, safranal, and kaempferol, which can help protect cells from oxidative stress and reduce the risk of chronic diseases.
- Eye Health: The antioxidants in saffron, particularly crocin, may be beneficial for eye health. Studies suggest that saffron supplementation could improve retinal function and visual acuity in certain eye conditions, such as age-related macular degeneration.
- Memory and Cognitive Function: Some research indicates that saffron may have neuroprotective properties and could enhance memory and cognitive function, potentially benefiting conditions like Alzheimer’s disease.
- Heart Health: Saffron may have a positive impact on heart health by reducing risk factors such as high blood pressure and cholesterol levels.
- Appetite Control and Weight Management: Some studies suggest that saffron may help suppress appetite and reduce snacking, which can be beneficial for weight management.
- Premenstrual Syndrome (PMS) Relief: Saffron has been found to alleviate symptoms of PMS, such as irritability, headaches, cravings, and pain.
- Anti-inflammatory Properties: The compounds in saffron may have anti-inflammatory effects, which can be beneficial in reducing inflammation-related conditions.
It’s important to note that while saffron has many potential health benefits, much research is needed to fully understand its effects and optimal dosages. Additionally, saffron is a potent spice, and high doses can be toxic, so it should be consumed in moderation.
Zeolites
Zeolites are a class of microporous, aluminosilicate minerals commonly used as commercial adsorbents and catalysts. Due to their porous structure and ability to exchange cations, zeolites have been studied for their potential to remove heavy metals from various mediums.
Here’s what you should know about zeolites and heavy metal chelation:
- Adsorption, Not Chelation: Technically, zeolites adsorb heavy metals rather than chelate them. Chelation involves a molecule binding to a metal ion through multiple sites. In contrast, zeolites adsorb metal ions onto their surface or trap them within their porous structure through cation exchange.
- Applications:
- Water Treatment: Zeolites have been used in water treatment processes to remove heavy metals like lead, cadmium, and nickel from water.
- Soil Remediation: Zeolites can be applied to soils contaminated with heavy metals to adsorb and immobilize these metals, reducing their bioavailability and potential harm.
- Efficiency: The efficiency of zeolites in removing heavy metals depends on several factors, including:
- The type of zeolite used.
- The specific heavy metal being targeted.
- The concentration of the metal.
- The presence of other competing ions.
- pH and temperature conditions.
- Modified Zeolites: Natural zeolites can be modified to enhance their capacity for heavy metal adsorption. This can be done by treating zeolites with certain agents, like acids or chelating agents, to increase their cation exchange capacity or selectivity for specific metals.
- Safety in Ingestion: Some products on the market propose the ingestion of zeolites (like in the form of a liquid suspension) as a detox remedy for removing heavy metals from the body. However, the safety and efficacy of ingesting zeolites for this purpose are still subjects of debate. If considering such products, it’s essential to consult with a healthcare professional.
In summary, zeolites can adsorb heavy metals and are used in applications like water treatment and soil remediation. However, if considering zeolites for personal health reasons, especially ingestion, it’s crucial to approach with caution and seek guidance from health experts.
Zeolites are a class of microporous, aluminosilicate minerals commonly used as commercial adsorbents and catalysts. Due to their porous structure and ability to exchange cations, zeolites have been studied for their potential to remove heavy metals from various mediums.
Here’s what you should know about zeolites and heavy metal chelation:
- Adsorption, Not Chelation: Technically, zeolites adsorb heavy metals rather than chelate them. Chelation involves a molecule binding to a metal ion through multiple sites. In contrast, zeolites adsorb metal ions onto their surface or trap them within their porous structure through cation exchange.
- Applications:
- Water Treatment: Zeolites have been used in water treatment processes to remove heavy metals like lead, cadmium, and nickel from water.
- Soil Remediation: Zeolites can be applied to soils contaminated with heavy metals to adsorb and immobilize these metals, reducing their bioavailability and potential harm.
- Efficiency: The efficiency of zeolites in removing heavy metals depends on several factors, including:
- The type of zeolite used.
- The specific heavy metal being targeted.
- The concentration of the metal.
- The presence of other competing ions.
- pH and temperature conditions.
- Modified Zeolites: Natural zeolites can be modified to enhance their capacity for heavy metal adsorption. This can be done by treating zeolites with certain agents, like acids or chelating agents, to increase their cation exchange capacity or selectivity for specific metals.
- Safety in Ingestion: Some products on the market propose the ingestion of zeolites (like in the form of a liquid suspension) as a detox remedy for removing heavy metals from the body. However, the safety and efficacy of ingesting zeolites for this purpose are still subjects of debate. If considering such products, it’s essential to consult with a healthcare professional.
EDTA chelation IVs
EDTA (ethylene diamine tetraacetic acid) is a synthetic compound that has been used as a chelating agent for several decades. When introduced into the bloodstream, EDTA binds to heavy metals and minerals, facilitating their removal from the body through urine. The process of using EDTA to bind and eliminate heavy metals from the bloodstream is referred to as EDTA chelation therapy.
Here’s what you should know about EDTA chelation therapy:
- Approved Uses:
- Lead Poisoning: EDTA chelation therapy is FDA-approved for treating severe lead poisoning. In this context, EDTA binds to lead in the bloodstream, and the EDTA-lead complex is subsequently excreted in the urine.
- Other Heavy Metal Poisonings: EDTA can also be used in cases of poisoning with other metals like mercury, arsenic, and cadmium, although its use might be specific to the type and severity of poisoning.
- Controversial Uses:
- Cardiovascular Disease: Some proponents suggest that EDTA chelation therapy can reduce the risk of cardiovascular disease by removing calcium deposits from arteries (a concept sometimes called “roto-rootering” the arteries). However, evidence supporting this use is limited and controversial. The American Heart Association and the American College of Cardiology do not recommend EDTA chelation therapy for heart disease patients due to a lack of evidence demonstrating its efficacy.
- Autism and other Disorders: Some alternative medicine practitioners have proposed EDTA chelation as a treatment for autism, under the belief that heavy metal toxicity contributes to the condition. This use is controversial and not supported by substantial scientific evidence. Moreover, there have been serious adverse events, including fatalities, linked to the use of chelation therapies in children with autism.
- Risks and Side Effects:
- EDTA chelation therapy can have side effects. These might include headaches, nausea, hypocalcemia (low calcium levels in the blood), hypotension (low blood pressure), and kidney damage.
- There’s also the risk that EDTA might chelate essential minerals, leading to mineral deficiencies.
- Procedure:
- Typically, EDTA chelation therapy is administered intravenously (IV) over several sessions. The specific dosage and number of treatments can vary based on the intended purpose and the patient’s health status.
- Considerations:
- If considering EDTA chelation therapy for any reason, it’s crucial to consult with a knowledgeable and experienced healthcare provider.
- It’s also important to understand the potential risks and benefits, as well as the level of evidence supporting the intended use.
In summary, while EDTA chelation therapy has established uses in the context of specific heavy metal poisonings, its application for other conditions, like cardiovascular disease or autism, remains controversial and requires careful consideration.
Ascorbyl Palmitate
Many products such as Biotics Research Omega-3 contain this “stabilizer”. Ascorbyl palmitate and ascorbic acid are not the same, although they are related. Ascorbyl palmitate is an ester formed from ascorbic acid (vitamin C) and palmitic acid. It’s a fat-soluble form of vitamin C, whereas ascorbic acid is water-soluble. Ascorbyl palmitate is often used in food processing as an antioxidant preservative and can also be found in skin care products due to its antioxidant properties.
Because it’s fat-soluble, ascorbyl palmitate is more stable than water-soluble forms of vitamin C, especially when it comes to heat and oxidation. This is why it’s often used in foods, cosmetics, and skin care products that contain fats and oils, as it helps prevent them from becoming rancid?
Ascorbic acid (vitamin C) is hydrophilic, meaning it is water-soluble and tends not to interact well with lipid (fat) components. In contrast, omega-3 fatty acids are lipophilic and part of the cell membrane, which is a lipid bilayer.
When ascorbic acid is esterified to form ascorbyl palmitate, the resultant molecule has both hydrophilic (ascorbic acid) and lipophilic (palmitic acid) components. This allows it to be more soluble in lipids and hence to interact with the cell membrane.
However, this interaction could potentially result in the oxidation of sensitive fatty acids like omega-3s in the membrane, thereby leading to lipid peroxidation and cell damage. Essentially, the antioxidant behavior of ascorbic acid could be compromised when it’s part of a molecule that interacts with lipids, leading to unintended oxidative damage.
The palmitic acid component in ascorbyl palmitate, which makes the compound lipid-soluble, could potentially lead to the generation of oxidized lipid metabolites. Oxidized lipids are generally considered pro-inflammatory and can be harmful to cells, including those in the skin’s epidermal layer.
While ascorbyl palmitate is often used in skin care products for its antioxidant benefits, its potential to contribute to lipid peroxidation is a concern that’s been raised in some scientific discussions. It’s essential to weigh the benefits and risks when considering the use of ascorbyl palmitate, especially for individuals with sensitive skin or pre-existing skin conditions.
Other potential side effects in some people:
- Allergic Reactions: Though rare, some individuals might be allergic to ascorbyl palmitate and could experience symptoms like itching, rashes, or more severe reactions.
- Gastrointestinal Issues: Some people might experience digestive upset, including diarrhea or abdominal cramps, although this is generally more of a concern with vitamin C in general, especially at high doses.
- Interactions: If you are taking any other medications or supplements, especially those that also have antioxidant properties, it’s a good idea to check for potential interactions.
- Preexisting Health Conditions: If you have certain health conditions, such as kidney disorders, excessive use of vitamin C could potentially be harmful. Consult your healthcare provider for guidance tailored to your health status.
Fiber and Fructose intolerance
Paleo humans are estimated to have consumed a significantly higher amount of dietary fiber compared to modern humans. While exact numbers can vary depending on the specific population and environment, studies suggest that Paleolithic diets likely included between 70 to 150 grams of fiber per day. This high intake was due to the consumption of large amounts of fruits, vegetables, nuts, seeds, and tubers. In contrast, the average fiber intake in modern Western diets is much lower, often around 15 to 20 grams per day.
There is a general consensus that taking fiber as a supplement is beneficial. However it can cause severe digestive problems and it is preferred to intake your ‘fiber’ with general food sources such as vegetables, grains and nuts.
Soluble fiber and insoluble fiber are two types of dietary fiber that have different characteristics and health benefits. Soluble fiber is a type of fiber that dissolves in water and forms a gel-like substance in the digestive tract. It is found in foods such as oat bran, nuts, seeds, legumes, and some fruits and vegetables. Soluble fiber is beneficial for heart health because it can help lower blood cholesterol and improve blood sugar control.
Insoluble fiber, on the other hand, does not dissolve in water and passes through the digestive system largely intact. It is found in foods such as whole grains, nuts, seeds, and the skin of some fruits and vegetables. Insoluble fiber is beneficial for digestive health because it can help promote regular bowel movements and prevent constipation.
Overall, a healthy diet should include a balance of both soluble and insoluble fiber to support optimal health. Soluble fiber is ONLY partially digested in the human digestive system. It dissolves in water to form a gel-like substance and is fermented by gut bacteria in the large intestine. This fermentation process produces short-chain fatty acids, which can be used as an energy source by the body. So, although soluble fiber is not fully digested, it still provides some nutritional benefits.
Zinzino offers Zinobiotic Prebiotics:
ZinoBiotic+ is a tailored blend of 8 natural dietary fibers. These fibers are metabolized in the colon (the large intestine) where they support the growth of healthy bacteria.* ZinoBiotic+ helps to reduce spiking in blood sugar after meals, and maintain cholesterol levels that are already within the normal range.
Fructose intolerance
There is a relationship between fiber and fructose intolerance, as both can affect the way the digestive system processes sugars. Fructose intolerance is a condition in which the body has difficulty digesting fructose, a type of sugar found in many fruits, vegetables, and sweeteners. When fructose is not properly absorbed in the small intestine, it can ferment in the large intestine and cause symptoms such as bloating, gas, and diarrhea.
Fiber, on the other hand, is a type of carbohydrate found in plant-based foods such as fruits, vegetables, and whole grains. It is not digested by the human body, but instead passes through the digestive system largely intact, helping to promote bowel regularity and prevent constipation.
In some cases, consuming high amounts of fiber can exacerbate fructose intolerance symptoms, as fiber can promote the growth of bacteria in the large intestine that produce gas and other byproducts during fermentation. However, for many people, fiber can actually help to alleviate digestive symptoms by promoting healthy bowel movements and reducing constipation.
If you have fructose intolerance, it may be helpful to work with a healthcare provider or registered dietitian to determine the best balance of fiber and other nutrients in your diet to support digestive health while minimizing symptoms.
- Rao, S. S., Yu, S., Fedewa, A. (2013). Systematic review: dietary fibre and FODMAP-restricted diet in the management of constipation and irritable bowel syndrome. Alimentary Pharmacology & Therapeutics, 38(7), 697- 716. doi: 10.1111/apt.12403
- Nanayakkara, W. S., Skidmore, P. M. L., O’Brien, L., Wilkinson, T. J., Gearry, R. B. (2016). Efficacy of the low FODMAP diet for treating irritable bowel syndrome: the evidence to date. Clinical and Experimental Gastroenterology, 9, 131- 142. doi: 10.2147/CEG.S86798
- Shepherd, S. J., Lomer, M. C. E., Gibson, P. R. (2013). Short-chain carbohydrates and functional gastrointestinal disorders. American Journal of Gastroenterology, 108(5), 707- 717. doi: 10.1038/ajg.2013.96
- Gibson, P. R., Shepherd, S. J. (2010). Evidence-based dietary management of functional gastrointestinal symptoms: The FODMAP approach. Journal of Gastroenterology and Hepatology, 25(2), 252- 258. doi: 10.1111/j.1440-1746.2009.06149.x
These studies discuss the role of fiber and fermentable carbohydrates (such as fructose) in the management of functional gastrointestinal disorders like irritable bowel syndrome. They suggest that a diet low in fermentable carbohydrates (such as the low FODMAP diet) may help alleviate symptoms of these conditions.
However this Fructose intolerance is likely related to Omega3 deficiency and the resulting high Omega6/3 index:
General Nutrition and Diets
Nutrition and dieting is the study of how food and nutrients affect the body’s health, growth, development, and overall well-being. It involves the process of consuming, digesting, absorbing, and utilizing nutrients from food to support various bodily functions and maintain optimal health. Nutrition also encompasses the study of dietary patterns, food choices, and their impact on health outcomes. The field of nutrition covers a wide range of topics, including macro and micronutrients, dietary supplements, metabolism, and chronic disease prevention and management.
In Chinese medicine, nutrition is seen as an essential aspect of health and well-being, and food is considered a form of medicine. The principles of Chinese medicine emphasize the importance of balancing the body’s energy or qi (pronounced “chee”) through dietary practices.
Chinese medicine identifies different types of foods based on their energetic qualities, such as cooling, warming, moistening, and drying. It is believed that eating certain foods can help restore balance to the body and treat specific health conditions.
In addition to specific dietary recommendations, Chinese medicine also emphasizes the importance of mindful eating and taking the time to fully experience and savor each meal. The practice of eating in a calm and relaxed state is thought to aid digestion and promote overall health.
Overall, Chinese medicine views nutrition as an integral part of holistic health and wellness, and emphasizes the importance of a balanced and individualized approach to diet and nutrition.
Many people eat too much cold and raw food (such as banana and salads) causing the depletion of their yang qi… this has detrimental effects on their metabolism and the ability to loose weight or in other words they cannot properly digest the food they are eating. Also when we consume too many carbohydrates, our body breaks them down into glucose, which is then stored in our muscles and liver as glycogen. For every gram of glycogen stored, our body stores about 3-4 grams of water. This means that when we consume excess carbohydrates, our body stores more glycogen and consequently more water, leading to water retention. This is also why people often experience a rapid drop in weight when starting a low-carb or ketogenic diet, as their body starts to use up stored glycogen and release excess water.
The Tao of Nutrition is a concept that combines the principles of traditional Chinese medicine and nutrition to promote health and wellness. According to Taoist philosophy, food is viewed as a natural source of energy that can be used to support physical, emotional, and spiritual well-being. The goal of the Tao of Nutrition is to maintain a balanced and harmonious relationship between the individual and their environment through the foods that they consume.
In Chinese medicine, the concept of yin and yang is used to describe the complementary and interconnected forces that exist in all aspects of life, including food and nutrition. A balanced diet is one that includes foods that have both yin (cooling and moistening) and yang (warming and drying) properties. Additionally, each food has its own unique energetic properties that can affect different organs and systems in the body.
The Tao of Nutrition also emphasizes the importance of eating seasonally and locally grown foods to align with the natural rhythms of the environment. This approach aims to support the body’s natural cycles and prevent imbalances that can lead to disease. Other important aspects of the Tao of Nutrition include mindful eating, avoiding processed and refined foods, and incorporating a variety of different colors and flavors into the diet.
General Nutrition Table of Contents
-general dieting strategies and body types
Barley and Wheat
Strict Keto diets are great but not sustainable for ever and a body can typically not survive without carbs. This is called protein starvation.
Barley is a cereal grain that is a member of the grass family. It is one of the oldest cultivated crops in the world, and has been used for food, feed, and brewing for thousands of years.
Barley is a good source of dietary fiber, protein, and various vitamins and minerals, including vitamin B6, potassium, and selenium. It is also rich in antioxidants such as phenolic acids and flavonoids.
Barley is commonly used in the production of malt, which is used in the brewing of beer and whisky. It is also used as a food grain for human consumption, particularly in soups and stews, and as a feed grain for livestock.
In addition to its nutritional and culinary uses, barley has been used in traditional medicine for various ailments, including digestive issues, skin problems, and as a diuretic. Some studies have also suggested that the consumption of barley may have beneficial effects on cholesterol levels and cardiovascular health.
Wheat also has a long history in brewing, particularly in certain regions such as Belgium and Germany where wheat beers are popular. Wheat has a slightly different flavor profile than barley, which can contribute to the taste and texture of a beer. Additionally, wheat contains more protein than barley, which can give a beer a slightly hazy appearance and a fuller mouthfeel.
Overall, the choice of barley or wheat (or other grains such as rye or oats) in brewing depends on factors such as tradition, availability, flavor preferences, and the desired characteristics of the final product.
Buckwheat (Fagopyrum esculentum) is a plant cultivated for its grain-like seeds and used as a versatile food source. Despite its name, buckwheat is not related to wheat and is, in fact, gluten-free. It is a pseudocereal, similar to quinoa and amaranth, because it is consumed like a cereal grain but does not belong to the grass family.
Buckwheat has been a staple food in many traditional cuisines, particularly in Eastern Europe and Asia. It is available in various forms, such as groats (hulled seeds), flour, and noodles (like Japanese soba noodles).
Nutritional and health benefits of buckwheat:
- Gluten-free: Buckwheat is naturally gluten-free, making it a suitable option for individuals with celiac disease, gluten sensitivity, or those following a gluten-free diet.
- Rich in nutrients: Buckwheat is a good source of essential nutrients, such as manganese, magnesium, phosphorus, copper, and B vitamins (especially B2, B3, and B6). It also contains moderate amounts of protein and dietary fiber.
- High-quality protein: Buckwheat contains all nine essential amino acids, making it a complete protein source. This is relatively rare among plant-based foods and can be particularly beneficial for vegetarians and vegans.
- Antioxidant properties: Buckwheat contains antioxidants, such as rutin and quercetin, which can help protect the body from oxidative stress and reduce inflammation.
- Low glycemic index: Buckwheat has a low glycemic index (GI), meaning it causes a slower and more gradual rise in blood sugar levels after consumption. This can help manage blood sugar levels and may be beneficial for individuals with diabetes or those looking to improve their overall blood sugar control.
- Heart health: The fiber and antioxidants in buckwheat may help lower levels of bad cholesterol (LDL) and reduce the risk of heart disease.
Buckwheat can be used in various recipes, such as porridge, pancakes, bread, salads, and side dishes. When using buckwheat flour, keep in mind that it lacks gluten, so it may require additional binding agents or a mix with other flours to achieve the desired texture in baked goods.
Sourdough bread is made through a fermentation process that involves naturally occurring lactic acid bacteria and wild yeast. Although sourdough bread contains gluten, the fermentation process can modify the gluten content and make it more digestible for some individuals. However, it’s important to note that sourdough bread is not gluten-free and is not suitable for individuals with celiac disease or a severe gluten intolerance.
During the fermentation process, the lactic acid bacteria and wild yeast break down the carbohydrates and proteins in the dough, including gluten. This breakdown results in the production of organic acids, such as lactic acid and acetic acid, which contribute to the characteristic sour taste of sourdough bread. The fermentation process also leads to the production of enzymes, which can further break down gluten proteins into smaller fragments.
The breakdown of gluten proteins during fermentation may make sourdough bread more digestible for some individuals with non-celiac gluten sensitivity, as the gluten proteins are partially pre-digested. This can potentially result in reduced gastrointestinal symptoms compared to consuming traditional bread made with baker’s yeast.
However, while the fermentation process in sourdough can modify the gluten content and make it more digestible, it does not eliminate gluten entirely. Sourdough bread still contains gluten, and it is not safe for individuals with celiac disease or severe gluten intolerance to consume. For those with gluten-related disorders, it’s essential to choose certified gluten-free bread made with alternative grains, such as rice, quinoa, or sorghum.
Banana
As mentioned above in Traditional Chinese Medicine (TCM), foods are often categorized by their energetic properties, such as “hot,” “cold,” or “neutral.” This categorization is based on the observed effects of these foods on the body’s balance and energy, known as Qi, rather than their physical temperature or spiciness. The classification of bananas as a “cold” food in TCM is only to some degree directly related to their sugar content, but also to the general effects they are believed to have on the body. Naturally this makes sense since they grow in the Tropics. In that regard it is not advisable to eat this fruit during the cold winter month.
Here are some reasons why bananas are considered “cold” in TCM:
- Energetic Temperature: In TCM, bananas are thought to have a cooling effect on the body. This means they are believed to help clear heat and cool the blood, which can be beneficial in balancing conditions characterized by excess heat or inflammation according to TCM principles.
- Balancing Effects: Foods in TCM are selected to help balance the body’s Yin and Yang energies. “Cold” foods like bananas are often recommended for conditions where there is too much Yang (heat) energy, such as fever, hypertension, or skin rashes.
- Digestive Impact: Bananas are also considered to be moistening and are sometimes recommended for their ability to lubricate the intestines and aid in digestion, particularly in cases of dryness or constipation. This property contributes to their “cold” categorization. However their cold nature can also cause constipation.
- Holistic View of Food: TCM views food and diet holistically, where the nature of food, its flavor, and its organ associations all play a role in its categorization and use. The “cold” nature of bananas is part of this holistic understanding, where the overall impact on the body’s energy and balance is considered.
The concept of “cold” and “hot” foods in TCM is part of a broader dietary philosophy that is very different from Western nutritional science. It’s important to understand that these concepts are rooted in traditional beliefs and practices and may not align with modern nutritional science. Nonetheless, they are an integral part of TCM dietary therapy and are used to promote health and well-being within the context of this traditional system.
Dieting:
There is NO ‘ONE’ DIET for all. Every diet has be individualized on health needs and ethnic requirements. Dieting can be stressful and overwhelming and unpractical. Our goal is to come up with a simple approach that delivers sustainable results. Overall, it’s most important to note that the extent to which a person’s metabolism slows down on a ketogenic or fasting diet can vary based on factors such as their starting weight, body composition, and activity level.
When creating an individualized diet plan, several factors should be considered:
- Nutritional needs: Age, sex, body size, and activity level are some factors that influence an individual’s daily calorie and nutrient requirements. A well-balanced diet should provide sufficient energy and essential nutrients, such as proteins, fats, carbohydrates, vitamins, and minerals, to maintain optimal health.
- Health conditions: Certain medical conditions may require specific dietary adjustments. For example, people with diabetes need to carefully manage their carbohydrate intake, while those with kidney disease might need to limit their protein, sodium, and potassium consumption.
- Allergies and intolerances: Food allergies and intolerances can significantly impact an individual’s diet. Common allergens, such as nuts, gluten, and dairy, must be avoided if one has allergies or intolerances to these foods.
- Lifestyle factors and budget: Physical activity level, occupation, and daily routines can influence dietary needs. Athletes and individuals with physically demanding jobs may require more calories and nutrients to support their increased energy expenditure. Good food is expensive but there is generally no replacement for it.
- Ethnic and cultural considerations: Food preferences and dietary habits can be influenced by cultural and ethnic backgrounds. It is essential to respect and incorporate these factors into a diet plan to ensure that it is enjoyable, sustainable, and aligned with one’s cultural values.
- Personal preferences and beliefs: Individual tastes, food preferences, and dietary beliefs should also be taken into account when designing a diet plan. Some people may choose to follow vegetarian, vegan, or other specific dietary patterns based on personal beliefs or preferences.
By taking all these factors into consideration, healthcare professionals, nutritionists, or dietitians can create a personalized diet plan that meets an individual’s unique needs, preferences, and health goals.
Weight loss
Traditional ways of losing weight make most (not all) hormonal body functions worse. When your body becomes overwhelmed by stress, it starts to pump out excess cortisol, the belly fat hormone. Dieting means starving the body; exercise is stress to the body. Anything that adds stress makes the weight loss problem worse. This is why those sit-ups never worked – because contracting your abdominal muscles do not lower cortisol.
In modern carbohydrate heavy diets (eg. “healthy oatmeal for breakfast”) there is an inflammatory roller coaster of blood sugar present. Insulin is secreted every time by the pancreas when the blood sugar becomes too high. The sudden release of insulin then causes a cortisol secretion by the adrenal glands because your blood sugar gets too low. When a person eats refined food, it gets absorbed into the bloodstream pretty quickly, which spikes up the blood sugar levels. So again, this causes a surge of insulin to be released from the pancreas, which in effect lowers the blood sugar levels. If the blood sugar levels dip too low, such as when someone goes a long time without eating anything, then cortisol will be released to raise the blood sugar levels. So for someone that eats refined foods it creates a viscous cycle that puts a lot of stress on their body. This makes weight loss almost impossible. You are also putting yourself at risk for developing diabetes with all of its complications.
Most people think that they need to lose weight in order to be healthy. IT IS THE OPPOSITE: YOU NEED TO BE HEALTHY IN ORDER TO LOSE WEIGHT! When your digestion and your body functions are optimal, it is much easier to loose weight. For example, if you have chronic pain, your cortisol levels are high which in turn increases your insulin levels, a major contributor to fat storage.
Simply putting your focus on eating fewer calories than you burn is a losing strategy. This oversimplified numerical approach treats all calories as equal — which they are not. The nature and quality of those calories matter.
Our bodies require a consistent balance of healthy macro-nutrients (protein, fat, and carbohydrates), as well as micronutrients (vitamins, minerals, antioxidants, phytochemicals), plus adequate phytonutrients, enzymes, fiber, water, and so on in order to function optimally.
When we are missing these elements, our energy levels drop, our hormones and neurotransmitters get imbalanced, and our metabolism stops working efficiently. Our vitality suffers, and our bodies don’t regulate much of anything (including our weight and body composition) as they are designed to.
The “yo-yo effect” (sometimes spelled “jojo effect”) is a phenomenon that occurs when a person experiences a cycle of losing and regaining weight repeatedly. This is also known as “weight cycling” or “yo-yo dieting.” The term comes from the yo-yo toy, which moves up and down a string, similar to the way a person’s weight fluctuates in this pattern.
The yo-yo effect often happens when someone follows a restrictive or fad diet for a short period, loses weight, and then returns to their previous eating habits, causing them to regain the lost weight or even gain additional weight. This cycle can be frustrating and demoralizing and can negatively impact a person’s physical and mental health.
Possible reasons for the yo-yo effect include:
- Unsustainable diets: Many fad or crash diets are overly restrictive, making them difficult to maintain in the long term. When people return to their old eating habits, they are likely to regain the weight they lost.
- Metabolic adaptations: Rapid weight loss can lead to a decrease in resting metabolic rate (RMR), which is the number of calories your body needs to maintain its basic functions at rest. A lower RMR means your body burns fewer calories, making it easier to regain weight once you resume your normal eating habits.
- Loss of muscle mass: During rapid weight loss, the body may lose muscle mass along with fat. Since muscle is more metabolically active than fat, a decrease in muscle mass can contribute to a lower RMR and make it more challenging to maintain weight loss.
- Hormonal changes: Weight loss can lead to hormonal changes that stimulate appetite and promote fat storage, making it harder to maintain weight loss in the long term.
To avoid the yo-yo effect, it is essential to adopt a sustainable approach to weight loss that focuses on long-term lifestyle changes, including a balanced diet and regular physical activity. Consulting a healthcare professional or registered dietitian can help you create a personalized weight loss plan that supports your goals and promotes lasting results.
different individuals have unique genetic predispositions, metabolism, and hormone levels that influence how they gain weight, lose weight, or maintain their health. However, there is limited scientific evidence to support the idea that specific diets should be prescribed based on body type alone.
Three common body types are often discussed: ectomorph, mesomorph, and endomorph. These body types are described as follows:
- Ectomorph: Typically characterized by a lean and slender frame, long limbs, and a fast metabolism. Ectomorphs may have difficulty gaining weight and muscle mass.
- Mesomorph: Usually characterized by a muscular and athletic build, broad shoulders, and a naturally higher proportion of muscle mass. Mesomorphs may find it relatively easier to gain or lose weight and build muscle.
- Endomorph: Generally characterized by a larger frame, higher body fat percentage, and a slower metabolism. Endomorphs may find it harder to lose weight and may be more prone to storing fat.
Although it can be helpful to understand your body type in western terms, Chinese Medicine has a different approach.
TCM CAN BALANCE YOUR ORGAN FUNCTION, MAINLY LIVER, KIDNEY, LUNG AND HEART
TCM CAN IMPROVE YOUR DIGESTION DRAMATICALLY. HEALTH STARTS AT THE DIGESTIVE FUNCTION.
TCM CAN CHANGE YOUR BODY IMBALANCES LONG TERM.
TCM UNDERSTANDS YOUR BODY TYPE AND SETS ‘REALISTIC’ GOALS.
THE 4 “PROBLEMATIC” BODY TYPES THAT CAN LEAD TO EXCESS WEIGHT GAIN OR OBESITY.
-Liver
-Thyroid
-Adrenal
-Ovary/Testicle
The ADRENAL body type will have a tendency to a sagging belly and a buffalo hump. The OVARY body types will have fat collected on the hips and thighs. The THYROID body type will collect fat all over the body and especially in the limbs. And the LIVER type will have a protruding “beer” belly.
Diet, Inflammation and Gluten intolerance
As you can understand that dieting becomes so much easier when your bodies inflammation is down and cortisol levels are down.
This process is controlled by omega3 and the inflammatory index. Scientific evidence to suggest that achieving an omega-6/3 ratio below 4:1 can resolve gluten intolerance. Gluten intolerance, also known as non-celiac gluten sensitivity (NCGS), is a condition where individuals experience adverse symptoms after consuming gluten-containing foods, even though they do not have celiac disease or a wheat allergy.
The relationship between omega-6 and omega-3 fatty acids and gluten intolerance is not well-established. Omega-6 and omega-3 fatty acids are essential fatty acids that play crucial roles in the body’s inflammatory response, cell membrane structure, and overall health. An imbalance in the omega-6/3 ratio, particularly a high omega-6 intake relative to omega-3 intake, has been linked to increased inflammation and a higher risk of chronic diseases.
Gluten intolerance is thought to involve a set of mechanisms, primarily related to the inflammation and immune system’s response to gluten proteins found in wheat, barley, and rye. This errand immune response will be much lower in a less inflammatory body. However you have to understand that the gluten molecule is inherently hard to digest because of its sized and protein coat.
Gluten is a complex mixture of proteins found in wheat, barley, and rye. It is composed of two main protein groups: gliadins and glutenins. These proteins have different structures and properties, which contribute to the elasticity and texture of dough in gluten-containing grains.
It is not accurate to describe gluten as a single molecule because it consists of various proteins with different molecular weights and sizes. Gliadins and glutenins are made up of numerous individual proteins, each with its own molecular weight and structure.
Gliadins, which are responsible for the extensibility of dough, are smaller proteins with molecular weights ranging from approximately 30 to 55 kilodaltons (kDa). Glutenins, on the other hand, are larger, complex proteins responsible for the dough’s elasticity and strength. Glutenins can have molecular weights ranging from 100 to several hundred kilodaltons.
When flour is mixed with water, the gliadin and glutenin proteins interact to form a network that provides structure and texture to the dough. In individuals with celiac disease or gluten sensitivity, specific peptides within the gliadin proteins can trigger an immune response, leading to various symptoms and potential intestinal damage.
Leaky gut, also known as increased intestinal permeability, is a condition where the lining of the small intestine becomes damaged, allowing undigested food particles, toxins, and microbes to pass through and enter the bloodstream. This can trigger an immune response, leading to inflammation and a variety of health issues.
The relationship between leaky gut and inflammation can be explained through the following mechanisms:
- Damage to the intestinal barrier: The intestinal barrier, which is made up of tight junctions between the cells lining the gut, acts as a selective filter, allowing nutrients to pass through while keeping harmful substances out. When this barrier is compromised due to factors such as poor diet, stress, medications, or infections, substances that are not supposed to enter the bloodstream can do so, causing an immune response.
- Immune response: When foreign particles and toxins from the gut enter the bloodstream, the immune system recognizes them as threats and activates an inflammatory response to neutralize and remove them. This inflammation can be localized to the gut or systemic, affecting other organs and tissues in the body.
- Chronic inflammation: If the underlying causes of leaky gut are not addressed, the intestinal permeability may persist, leading to ongoing exposure to harmful substances and a continuous immune response. This can result in chronic inflammation, which has been associated with various health conditions, such as autoimmune diseases, allergies, skin disorders, and mental health issues.
- Dysbiosis: Leaky gut can also be linked to an imbalance in the gut microbiota, known as dysbiosis. An unhealthy gut microbiome can contribute to inflammation, further exacerbating intestinal permeability and the overall inflammatory response.
In summary, leaky gut and inflammation are related in that damage to the intestinal barrier can lead to the passage of harmful substances into the bloodstream, triggering an immune response and inflammation. This relationship underscores the importance of maintaining a healthy gut through a balanced diet, stress management, and appropriate use of medications. If you suspect you have leaky gut or are experiencing symptoms associated with inflammation, consult a healthcare professional for evaluation and guidance on appropriate treatment strategies.
Inflammatory Grains
Rice is a much better source of carbohydrates than Wheat. Both Wheat and rice belong to the family of Poaceae but they have little in common.
- Rice (Oryza spp.):
- Primary species: Oryza sativa (Asian rice) and Oryza glaberrima (African rice).
- Belongs to the grass family Poaceae.
- Cultivated in wetland conditions or paddy fields of subtropical climates..
- Wheat (Triticum spp.):
- Common species: Triticum aestivum (common wheat) and Triticum durum (used for pasta).
- Also part of the Poaceae family but thrives in temperate, dry climates environments.
Here are the highlights:
- Wheat is 10:1 inflammatory with a 17 times higher omega6 content than rice (see tables below)
- Rice does not contain gluten
- White rice has a neutral pH and lacks strong flavors or compounds that could irritate the stomach
- Wheat Contains more phytic acid and other antinutrients
When comparing white rice to wheat (especially in the form of white flour or whole wheat), several factors contribute to their differences in digestibility:
Fiber Content
- White Rice: Low in fiber because the bran and germ are removed during processing, making it easier to digest.
- Wheat:
- Whole Wheat: Higher in fiber due to the bran and germ being intact, which can make it more challenging to digest, especially for individuals with sensitive digestion.
- White Flour (Refined Wheat): Similar to white rice in low fiber content, so it’s comparably easy to digest.
Gluten Content
- White Rice: Naturally gluten-free, making it suitable for people with gluten intolerance or celiac disease. This also contributes to easier digestion for sensitive individuals.
- Wheat: Contains gluten, a protein that can be difficult for some people to digest. Gluten can cause inflammation or discomfort in those with gluten sensitivities or disorders.
Starch Composition
- White Rice: Primarily contains easily digestible starch (amylopectin), which breaks down quickly into glucose.
- Wheat: Also rich in starch but contains more amylose, a starch that takes longer to digest. Wheat’s starch may also be less digestible due to its interactions with gluten.
Antinutrients
- White Rice: The milling process removes most antinutrients like phytic acid, which can hinder digestion.
- Wheat:
- Whole Wheat: Contains more phytic acid and other antinutrients, which can impair mineral absorption and make digestion more difficult.
- White Flour: These compounds are largely removed during refining, improving digestibility.
Cooking and Preparation
- White Rice: Becomes very soft when cooked, reducing the digestive workload.
- Wheat: Products like bread or pasta may vary in texture and density, with denser whole wheat products being harder to digest than refined wheat products.
Nutrient and Digestive Load
- White Rice: Simplified composition with fewer nutrients means fewer digestive enzymes are needed, making it gentler on the stomach.
- Wheat: Even refined wheat retains a more complex nutrient profile (e.g., small amounts of protein from gluten), which can be more taxing on digestion.
Suitability for Digestive Issues
- White Rice: Often recommended for sensitive digestion (e.g., during recovery from illness, diarrhea, or gastrointestinal distress) due to its blandness and ease of breakdown.
- Wheat: Refined wheat may be easy to digest for most people, but gluten or whole wheat fiber can irritate sensitive stomachs.
Summary:
- Easier to Digest: White rice is generally easier to digest than both whole wheat and refined wheat products due to its low fiber, lack of gluten, and simple starch profile.
- Complex Digestibility: Wheat, particularly whole wheat, can be harder to digest due to its fiber and gluten content, but refined wheat products are closer to white rice in digestibility.
White rice is easier to digest than brown rice or other whole grains due to the following reasons:
Removal of Bran and Germ
- White rice is milled to remove the bran and germ layers, leaving just the starchy endosperm. This process reduces fiber content, which can make it gentler on the digestive system, especially for people with sensitive stomachs or digestive disorders.
Low Fiber Content
- Unlike brown rice, which contains more insoluble fiber from the bran layer, white rice has minimal fiber. While fiber is generally beneficial for digestion, it can be harder for some people to break down, particularly during gastrointestinal distress.
Simpler Starch Composition
- The starches in white rice are more readily broken down by digestive enzymes into glucose, making it a quicker source of energy. Brown rice has more resistant starch, which can ferment in the gut and cause gas or bloating in sensitive individuals.
4. Neutral pH and Blandness
- White rice has a neutral pH and lacks strong flavors or compounds that could irritate the stomach, making it suitable for bland diets often prescribed for individuals recovering from illness.
Lack of Antinutrients
- The milling process removes antinutrients like phytic acid, present in the bran and germ of whole grains, which can interfere with nutrient absorption and be harder on the digestive system.
Soft Texture After Cooking
- When cooked, white rice becomes soft and mushy, making it easier for the stomach to process compared to firmer whole grains.
This is why white rice is often recommended in low-residue or soft diets for individuals recovering from digestive issues, surgery, or illness.
Wheat is higher in fiber, magnesium and calories but it comes at a big price as explained above. Specifically its much higher 10:1 omega6/3 inflammatory index and the 17 times higher overall omega6 content. In contrast rice has an index of only 2:1. Keep in mind these values vary depending on species, harvest and soil.
Carb cycling is a dietary strategy in which you alternate between periods of high-carb eating and low-carb eating. The goal of carb cycling is to optimize the body’s ability to use carbohydrates for energy while minimizing the storage of fat. The specific approach to carb cycling can vary depending on an individual’s goals, but generally involves cycling between high-carb and low-carb days or weeks. This approach is often used by athletes and bodybuilders to maximize their performance and physique, but can also be used by individuals looking to manage their weight or improve their overall health.
In other words during a prolonged keto-diet the body’s metabolism can slow down due to a few factors:
- Reduced thyroid hormone production: The body may produce less of the thyroid hormone triiodothyronine (T3) when carbohydrate intake is low, which can lead to a slower metabolism.
- Decreased muscle mass: When carbohydrate intake is low, the body may break down muscle protein for energy, leading to a decrease in overall muscle mass. Since muscle burns more calories at rest than fat, a decrease in muscle mass can lead to a slower metabolism.
- Reduced spontaneous physical activity: Some people may experience a decrease in spontaneous physical activity on a keto diet due to lower energy levels or a lack of glycogen stores, which can also lead to a slower metabolism.
- Adaptive thermogenesis: When the body is in a calorie deficit for an extended period, it may adapt by lowering its energy expenditure to conserve energy. This can result in a slower metabolism.
Keto and Paleo
The ketogenic (keto) diet is a low-carbohydrate, high-fat, and moderate-protein eating plan designed to shift the body’s primary source of energy from glucose (derived from carbohydrates) to ketones (derived from fats). This metabolic state, known as ketosis, is achieved by significantly reducing carbohydrate intake and increasing fat intake.
On a typical keto diet, about 70-80% of calories come from fat, 5-10% from carbohydrates, and 10-20% from protein. By drastically reducing carbohydrate intake and increasing fat consumption, the body is forced to break down stored fat for energy. This results in the production of molecules called ketones, which are used by the body and brain for energy.
The keto diet is often used for weight loss, as it can help to reduce appetite and promote fat burning. It has also been used as a therapeutic diet for certain medical conditions, such as epilepsy, type 2 diabetes, and some neurological disorders.
However, the keto diet is not suitable for everyone and can have side effects, such as the “keto flu” during the initial transition period, and it may not be sustainable in the long term. It is important to speak with a healthcare provider before starting the keto diet or any other dietary changes.
Here’s a brief explanation of the keto diet:
- Macronutrient distribution: The typical macronutrient distribution for a keto diet is around 70-80% of calories from fats, 10-20% from protein, and 5-10% from carbohydrates. This distribution varies among individuals, but the principle of consuming very low carbs remains consistent.
- Food choices: The diet emphasizes whole, minimally processed foods high in healthy fats, such as avocados, nuts, seeds, olives, coconut oil, and grass-fed butter. It also includes moderate amounts of high-quality protein sources, such as meat, poultry, fish, and eggs. Non-starchy vegetables, like leafy greens, are encouraged for their low carbohydrate content and high nutrient density. Foods high in carbohydrates, such as bread, pasta, grains, starchy vegetables, and most fruits, are greatly limited or avoided altogether.
- Ketosis: By significantly reducing carbohydrate intake, the body becomes more efficient at burning fat for fuel. This process produces ketone bodies, which are used as an alternative energy source for the brain and other organs. Ketosis can be monitored through various methods, such as blood, urine, or breath testing.
- Potential benefits: Advocates of the keto diet claim that it can lead to weight loss, improved mental clarity, increased energy levels, and better blood sugar control. Some research supports these claims, but more long-term studies are needed to fully understand the diet’s effects on overall health.
- Potential risks: The keto diet may not be suitable for everyone, and some individuals may experience side effects, such as the “keto flu,” which consists of flu-like symptoms as the body adapts to using ketones for fuel. Additionally, the diet can be challenging to maintain long-term, and there is a risk of nutrient deficiencies if not properly balanced.
How is Paleo different?
Both the ketogenic (keto) and Paleolithic (paleo) diets are popular eating plans that emphasize whole, minimally processed foods and aim to improve overall health. However, they differ in their macronutrient distribution, food choices, and underlying principles. Here are the main differences between the keto and paleo diets:
- Macronutrient distribution:
- Keto: The primary goal of the keto diet is to reach and maintain a state of ketosis by consuming high amounts of fats (70-80% of total calories), moderate protein (10-20%), and very low carbohydrates (5-10%).
- Paleo: The paleo diet does not have specific macronutrient ratios. Instead, it focuses on consuming foods that were available to our hunter-gatherer ancestors. The diet typically includes a higher protein intake, moderate fats, and relatively lower carbohydrates compared to a standard Western diet, but not as low as in the keto diet.
- Food choices:
- Keto: The keto diet encourages the consumption of high-fat foods such as avocados, nuts, seeds, and coconut oil. It limits or avoids high-carbohydrate foods, including grains, legumes, most fruits, and starchy vegetables. Dairy products are allowed in moderation, depending on individual tolerance.
- Paleo: The paleo diet encourages the consumption of lean meats, fish, vegetables, fruits, nuts, and seeds. It excludes grains, legumes, dairy, refined sugars, and processed foods. Unlike the keto diet, paleo allows for more carbohydrate consumption through fruits and starchy vegetables like sweet potatoes.
- Underlying principles:
- Keto: The primary goal of the keto diet is to achieve a metabolic state called ketosis, where the body relies on fat-derived ketones for energy instead of glucose from carbohydrates.
- Paleo: The paleo diet is based on the idea that eating foods similar to those consumed by our hunter-gatherer ancestors may improve health and reduce the risk of chronic diseases associated with modern diets.
- Weight loss and health benefits:
- Keto: Weight loss on the keto diet is primarily attributed to reduced carbohydrate intake, leading to lower insulin levels and increased fat burning. Other potential benefits include improved mental clarity, increased energy, and better blood sugar control.
- Paleo: Weight loss on the paleo diet may be attributed to the elimination of processed foods, refined sugars, and increased consumption of nutrient-dense whole foods. Potential benefits include improved digestion, reduced inflammation, and better blood sugar control.
Intermitted fasting
Intermittent fasting (IF) is an eating pattern that involves cycling between periods of fasting and eating. It does not prescribe specific foods or macronutrients; instead, it focuses on when you eat. The primary goal of intermittent fasting is to give the body a break from constant digestion, allowing it to utilize stored energy and repair itself more efficiently.
There are several popular intermittent fasting methods, including:
- 16/8 method (Leangains protocol): This method involves fasting for 16 hours each day and eating during an 8-hour window. For example, you might skip breakfast and eat your first meal at noon, then finish your last meal by 8 p.m.
- 5:2 method: This method involves eating a regular diet for five days a week and consuming only 500-600 calories on the remaining two non-consecutive days.
- Eat-Stop-Eat: This method involves fasting for a full 24 hours once or twice a week. For example, you might fast from dinner one day until dinner the next day.
- Alternate-day fasting: This method involves alternating between days of regular eating and days of fasting or consuming minimal calories (around 500-600).
- The Warrior Diet: This method involves fasting for 20 hours each day and eating a large meal, typically in a 4-hour window, in the evening.
Intermittent fasting is thought to work by:
- Improving insulin sensitivity: Fasting periods can help lower insulin levels and improve insulin sensitivity, allowing the body to use stored glucose more efficiently.
- Promoting fat loss: During fasting periods, the body taps into stored fat for energy, which can contribute to weight loss.
- Boosting metabolism: Short-term fasting has been shown to increase metabolic rate, which can further support weight loss efforts.
- Enhancing cellular repair: Fasting periods may promote autophagy, a cellular cleaning process that removes damaged proteins and organelles, potentially reducing the risk of chronic diseases and aging-related conditions.
- Supporting hormone regulation: Intermittent fasting may help regulate hormones related to weight loss and appetite control, such as human growth hormone (HGH) and leptin.
It is important to note that intermittent fasting may not be suitable for everyone, and certain individuals, such as pregnant or breastfeeding women, those with a history of eating disorders, or individuals with specific medical conditions, should consult a healthcare professional before trying intermittent fasting. Additionally, the long-term effects and optimal fasting methods may vary among individuals,
How does this fasting affect cortisol and inflammation?
Fasting has been with human evolution from day one. It takes effort to get food if there is no supermarket available and typically humans ate when they were really hungry and didn’t eat when the food was used up.
WATER
The human body consists of about 60% water although adipose tissue contains less water than lean tissue. How much plain water should you drink per day? Probably not very much. The general rule is: drink when you are thirsty and try to add a few drops for lime juice or other diluted electrolytes to the plain water. When you sweat during exercise or in extreme heat your body is naturally telling you to re-hydrate.
When drinking too much plain water, you may experience water poisoning and even a disruption of brain function. Cells can swell up and interstitial fluid gets stuck in your body. Most of the time excess water just stays in your abdomen before it finds a way to be excreted by the kidneys. It is important to “flush” the water out before it becomes a problem.
Sodium is the electrolyte most affected by overhydration leading to hyponatremia. Too much water although typically in excess of 20L per day can dilute the amount of sodium in your blood. EG. marathon runners while they are also losing sodium through their sweat. Sodium is a crucial element for your nervous function and osmotic balance. When its levels drop due to a high amount of water in the body, excess fluids get inside the cells so you really are not achieving healthy hydration. When the cells in the brain swell up they cause pressure in the brain drowsiness, and headaches. If this pressure increases it could even cause hypertension.
In summary, it is important to keep your mineral balance ‘as in so called isotonic drinks’ when hydrating. So add some diluted juice to your water or drink tea. Many natural drinks like beer or coffee and tea also act as diuretics so the excess water will be flushed out immediately. This helps the body to detoxify better. However below you will see salt intake is another aspect of this discussion.
Why Beef?
Beef is an excellent source of essential amino acids, but it is not necessarily richer in essential amino acids compared to other meat sources. The amino acid profile of various meats can be quite similar, and they all typically provide the essential amino acids needed for human health.
Here’s a comparison of the essential amino acid content in various meat sources (per 100 grams):
- Beef: Beef is a high-quality protein source, containing all nine essential amino acids in good amounts. It is particularly rich in leucine, lysine, and valine.
- Chicken: Chicken is also a high-quality protein source with a complete essential amino acid profile. The amino acid composition of chicken is quite similar to that of beef, with slight variations in the amounts of each amino acid.
- Pork: Pork is another good source of essential amino acids. Like beef and chicken, pork contains all nine essential amino acids, and the amino acid profile is relatively similar to both beef and chicken.
- Fish: Fish is a high-quality protein source with a complete essential amino acid profile. The composition of essential amino acids in fish can vary depending on the species but is generally comparable to that of other meat sources.
- Turkey: Turkey is also a complete protein source with a similar essential amino acid profile to chicken and beef.
While the essential amino acid content in these meat sources is relatively similar, the overall nutritional value can vary. Factors such as the cut of meat, cooking method, and fat content can influence the nutritional profile of each meat source. It is essential to include a variety of protein sources in your diet to ensure you are consuming a well-rounded mix of essential amino acids and other nutrients.
In Traditional Chinese Medicine (TCM), foods are classified based on their energetic properties and how they impact the body’s balance. Red meat, such as beef and lamb, is considered to have “warming” properties, which means that it helps to nourish and strengthen the body, enhance blood circulation, and boost energy levels. In contrast, poultry and fish are often considered to have more neutral or cooling properties.
There are several reasons why red meat might be considered more valuable in TCM compared to poultry or fish:
- Richer in nutrients: Red meat is an excellent source of essential nutrients such as iron, zinc, and vitamin B12. These nutrients are crucial for maintaining healthy blood and supporting the immune system. Iron, in particular, is more abundant and more easily absorbed from red meat than from poultry or fish.
- Warming properties: As mentioned earlier, red meat is believed to have warming properties in TCM, making it suitable for individuals who have a “cold” constitution or who suffer from certain conditions related to poor circulation, fatigue, or weakness.
- Strengthening effect: Red meat is thought to help build and strengthen the body due to its high protein content and abundance of essential amino acids. This makes it beneficial for individuals who need to rebuild their strength, such as those recovering from an illness or injury.
While red meat does provide certain nutritional benefits, it is still essential to include a variety of protein sources in your diet for optimal health. Eating a well-balanced diet that includes poultry, fish, and plant-based protein sources, in addition to red meat, can help ensure that you are consuming a diverse range of nutrients to support your overall health and well-being.
Omega-3 fatty acids are essential nutrients that play a crucial role in maintaining heart health, supporting brain function, and reducing inflammation.
While red meat can contain omega-3 fatty acids, the content is typically of course lower compared to fatty fish. In addition the omega-3 content in red meat varies depending on the animal’s diet, with grass-fed beef generally having a higher omega-3 content than grain-fed beef if it is grass-finished. However, even grass-fed beef has considerably lower levels of omega-3 compared to fatty fish like salmon, mackerel, and sardines and is probably not an adequate substitute especially in modern days.
Fish is considered one of the best dietary sources of omega-3 fatty acids, specifically EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), which have been widely studied for their health benefits.
In terms of omega-3 content, fish and seafood are more valuable sources than red meat or poultry. However, Traditional Chinese Medicine’s emphasis on red meat may not prioritize omega-3 content as highly as other nutritional factors. From a modern nutritional standpoint, it is essential to include a variety of protein sources in your diet, incorporating both red meat and fish to ensure you are consuming a diverse range of nutrients, including omega-3 fatty acids.
Here’s a table comparing the leucine content in beef and other common meats, per 100 grams of each type:
Meat Type | Leucine Content (per 100g) |
---|---|
Beef | 2.4g |
Chicken | 2.3g |
Pork | 2.3g |
Fish (Salmon) | 1.6g |
Turkey | 2.3g |
These values are average estimates and can vary based on the specific cut of meat and how it’s cooked. Beef tends to have a slightly higher leucine content compared to other meats, but the differences are not substantial.
Leucine is a key branched-chain amino acid (BCAA) known for its role in muscle building and repair. It’s particularly abundant in whey protein, making whey one of the most popular and effective sources for leucine supplementation, especially among athletes and bodybuilders.
Leucine Content in Whey:
- Whey Protein: Whey, a byproduct of cheese production, is a complete protein source that contains all nine essential amino acids, including a high concentration of leucine. On average, whey protein contains about 10% leucine by weight, which means that a 20-gram serving of whey protein provides approximately 2 grams of leucine.
- Types of Whey: There are different types of whey protein supplements, including whey protein concentrate, isolate, and hydrolysate. Whey protein isolate and hydrolysate typically have a slightly higher leucine content due to their higher protein concentration.
Safe Leucine Supplements:
- Whey Protein Supplements: As mentioned, these are a popular and effective way to increase leucine intake, especially post-workout for muscle recovery.
- BCAA Supplements: These supplements contain leucine along with the other two branched-chain amino acids, isoleucine, and valine, in various ratios. The most common ratio is 2:1:1 (leucine:isoleucine:valine).
- Leucine-Enriched Protein Supplements: Some protein supplements are specifically enriched with extra leucine.
- Vegan and Vegetarian Options: For those who prefer plant-based supplements, options like soy protein or branched-chain amino acid supplements that are derived from plant sources are available.
Considerations for Safety and Efficacy:
- Dosage: It’s important to follow the recommended dosages on supplement labels. Overconsumption of leucine can lead to imbalances in amino acid levels and potential gastrointestinal distress.
- Balance with Other Amino Acids: Leucine should be balanced with other amino acids, especially the other BCAAs, to ensure optimal protein synthesis and to avoid amino acid imbalances.
- Medical Conditions: Individuals with certain medical conditions, especially those affecting the kidneys or liver, should consult with a healthcare provider before taking leucine supplements.
- Quality of Supplements: Choose supplements from reputable brands that have third-party testing to ensure purity and quality.
In summary, whey protein is an excellent source of leucine, and there are various safe leucine supplements available. However, it’s important to consider factors like overall dietary protein intake, the balance of amino acids, individual health conditions, and the quality of the supplements when choosing and using leucine supplements.
Superfoods
A “superfood” is a term used to describe nutrient-rich foods that are considered to have significant health benefits. These foods are often high in vitamins, minerals, antioxidants, and other bioactive compounds that can help improve overall health, prevent chronic diseases, or boost energy levels.
It’s important to note that the term “superfood” is not a scientific classification but rather a marketing term used to promote and emphasize the health benefits of certain foods. While these foods can be nutritious and beneficial, it is crucial to maintain a balanced diet incorporating a wide variety of nutrient-dense foods to support optimal health.
Eggs, coconut, and avocado are often considered superfoods due to their nutrient-dense profiles. Here are some reasons why they are classified as such:
- Eggs: They are a great source of high-quality protein, containing all essential amino acids. Eggs are also rich in vitamins and minerals, such as vitamin B12, vitamin D, selenium, and choline, which is essential for brain health.
- Coconut: Coconut is known for its medium-chain triglycerides (MCTs), a type of fat that may boost metabolism and provide a quick source of energy. It is also a good source of manganese, copper, iron, and selenium. Additionally, coconut water is high in electrolytes, making it a natural hydration source.
- Avocado: Avocado is an excellent source of healthy monounsaturated fats, which can help improve heart health and reduce inflammation. It is also rich in fiber, potassium, vitamins C, E, K, and B vitamins, such as folate.
While these foods have notable health benefits, it’s essential to remember that a balanced diet, including a variety of fruits, vegetables, whole grains, lean protein, and healthy fats, is crucial for maintaining overall health.
List of plant foods that contain too much omega6
Caprylic Acid, MCT and Coconut
Coconut contains both saturated and unsaturated fats. The unsaturated fats, although present in smaller amounts compared to saturated fats, are more prone to oxidation. When exposed to air, heat, or light, these fats undergo oxidation, leading to the formation of volatile compounds that have a slightly rancid odor.
Caprylic acid, also known as octanoic acid, is a medium-chain fatty acid (MCFA) found in coconut oil, palm kernel oil, and the milk of certain mammals. It has been studied for various health benefits, particularly due to its antimicrobial properties and its role in gut health. Here are some of the key health benefits associated with caprylic acid:
1. Antimicrobial Properties:
Antifungal: Caprylic acid is effective against certain types of fungi, particularly Candida, a yeast that can cause infections in humans. It helps to break down the cell membranes of Candida, making it useful in managing Candida overgrowth and other fungal infections.
Antibacterial: Caprylic acid has antibacterial properties that can help inhibit the growth of harmful bacteria in the gut, such as Escherichia coli and Clostridium difficile, while promoting a healthy balance of gut flora.
Antiviral: Some studies suggest that caprylic acid may also have antiviral properties, although more research is needed in this area.
2. Gut Health:
Leaky Gut Syndrome: Caprylic acid may help in managing leaky gut syndrome, a condition where the intestinal lining becomes permeable, allowing toxins and undigested food particles to enter the bloodstream. By promoting the health of the gut lining and reducing inflammation, caprylic acid supports overall digestive health.
Digestive Health: Its antimicrobial action helps maintain a balanced gut microbiome, which is essential for proper digestion and nutrient absorption.
3. Anti-inflammatory Effects:
Caprylic acid may have anti-inflammatory effects, helping to reduce inflammation in the gut and other parts of the body. This can be particularly beneficial for individuals with inflammatory conditions, such as inflammatory bowel disease (IBD).
4. Weight Management and Energy:
Ketone Production: As a medium-chain triglyceride (MCT), caprylic acid is quickly metabolized by the liver and converted into ketones, which can be used as an immediate source of energy. This makes it beneficial for those following ketogenic diets or looking to enhance mental and physical performance.
Satiety: MCTs like caprylic acid may promote satiety, helping to reduce appetite and support weight management efforts.
5. Skin Health:
Antimicrobial and Moisturizing: Caprylic acid is often used in skincare products due to its antimicrobial properties and ability to help moisturize and protect the skin. It can be beneficial in treating conditions like acne and other skin infections.
6. Potential Neuroprotective Effects:
Cognitive Health: Some studies suggest that medium-chain fatty acids, including caprylic acid, might have neuroprotective effects and could be beneficial in managing neurodegenerative conditions like Alzheimer’s disease, though more research is needed to confirm these effects.
7. Immune Support:
By maintaining a healthy balance of gut bacteria and supporting digestive health, caprylic acid indirectly supports the immune system, which is closely linked to gut health.
Safety and Dosage:
While caprylic acid is generally considered safe for most people, high doses can cause gastrointestinal discomfort, such as nausea or diarrhea. It’s always best to start with a lower dose and gradually increase it, or consult a healthcare professional before adding it to your regimen.
In summary, caprylic acid offers various health benefits, particularly related to its antimicrobial properties, gut health support, and potential benefits in weight management and cognitive function.
Mustard Seeds
Mustard seeds are the small round seeds that come from various mustard plants. They are an important spice in many regional cuisines and they contribute to the local economies of many countries where they are cultivated.
There are three main types of mustard seeds:
- Yellow or white mustard seeds (Sinapis alba) – These are the mildest and are used in making traditional American yellow mustard.
- Brown mustard seeds (Brassica juncea) – These have a bit more pungency and are used in European, African, and Asian cuisines.
- Black mustard seeds (Brassica nigra) – These are the most pungent and flavorful, used in Indian cooking, for pickling, and in many other dishes.
Mustard seeds are high in selenium and omega-3 fatty acids. They also contain a range of other vital nutrients including dietary fiber, calcium, iron, manganese, magnesium, phosphorus, and zinc.
Creating a supplement facts label for mustard seeds might involve listing the following information, based on a 1-tablespoon serving size:
Supplement Facts show a high content of PUFA : Serving Size: 1 tbsp (9g) Amount Per Serving:
- Calories: 50
- Total Fat: 3.3g (5% DV)
- Saturated Fat: 0.2g (1% DV)
- Sodium: 0mg (0% DV)
- Total Carbohydrate: 3g (1% DV)
- Dietary Fiber: 1.8g (7% DV)
- Total Sugars: 0g
- Protein: 2.6g
- Vitamin A: 0% DV
- Vitamin C: 0% DV
- Calcium: 4% DV
- Iron: 6% DV
- Magnesium: 9% DV
- Selenium: 3% DV
In cooking, mustard seeds are often roasted in a skillet to bring out their aromatic and nutty flavor before being ground into a fine powder that’s used as a base for curry or added to stir-fry dishes. The seeds can also be soaked in water to create a spicy mustard paste.
From a health perspective, mustard seeds are touted for their potential benefits in reducing the symptoms of conditions like psoriasis and contact dermatitis. They’re also believed to aid in controlling symptoms of asthma and are known for their supposed cancer-fighting properties.
Nuts and other seeds
No, The phrase “this drives me nuts” is not related to nuts and it appears to have originated in the United States in the mid-20th century. The exact origin of the phrase is not well-documented, but its meaning is clear. If something “drives you nuts,” it annoys, frustrates, or confuses you to a great degree. The usage of “nuts” in this context is a colloquialism for “mad” or “crazy”, which itself derives from the older usage of “nut” to mean “head”.
Nuts are rich in unsaturated fats which are susceptible to oxidation. Once the nut is peeled or cracked open, these fats are exposed to oxygen, light, and heat, all of which can speed up the process of oxidation, leading to rancidity. Hence, pre-peeled or cracked nuts can potentially go rancid faster than those in shells.
The stability of a nut without its shell varies depending on several factors, including the type of nut, how it’s stored, and the environmental conditions it’s exposed to.
To prolong their shelf-life and avoid rancidity, nuts should be stored in a cool, dark, and dry place. Refrigeration or freezing can further prolong their freshness. Vacuum sealing or packaging in an inert gas can also reduce oxidation.
However, it’s important to note that even with these precautions, nuts can still eventually turn rancid due to the natural degradation of the fats they contain.
Also, it’s worth noting that rancidity does not mean that the food is unsafe to eat. Rancidity primarily affects taste and smell. However, consuming rancid food may not provide the same nutritional benefits as fresh food, and may contain potentially harmful compounds produced during the oxidation process.
It’s also important to note that commercially packed nut mixes may also contain added oils, sweeteners, or salt that can affect the stability and potential rancidity of the product.
If you notice a change in the smell or taste of the nuts (they may smell like paint or have a bitter or sour taste), it is best not to consume them as they are likely rancid.
Salt and other minerals
When talking about salt we typically mean Sodium Chloride. There are many other important mineral salts of course but the most important issue with consuming too much ‘table salt’ maybe that you are offsetting your sodium/potassium balance. This should also be addressed by proper supplementation but this can easily be tested by regular blood work.
Most Americans consume at least 1.5 teaspoons of salt per day, or about 3400 mg of sodium. That is not necessarily dangerous for your Kidney function unless you already have Kidney disease. However all that salt needs to go somewhere. Eating too much salt at one time will swell up your belly and make you bloated. In general, we eat too much and too fast but spreading it out over the course of the day is not usually a problem. In other words the salt actually activates your kidney function and flushes out more water from your body. That is, until your next salt loaded meal. Also keep in mind that many factors of inadequate digestion can cause you feel bloated.
Dr. Bombard even showed that humans can survive 6 days on just drinking sea water on a raft crossing the Atlantic ocean, you just have to do it in very small amounts at a time and he mixed the water with raw fish juice. However, kidneys cannot make urine from a concentration of salts of more than 2%. Seawater is made up of approximately 3% salt, so if we drink it to quench our thirst the kidneys have to use existing water from our body in order to dilute the extra salt, which in turn makes us feel even thirstier. But don’t despair. If you should be ship wrecked or your water purifier stops working all you have to do is use plastic water bottle or a pot to condensate and collect the pure water that evaporates with the help of the sun rays.
So in summary, there is a balance between salt and water and hydration and diuresis but also other nutrients. Many people loose 3-5 pounds of ‘weight’ in the first days of a keto diet. This is mostly excess water that the body holds onto because of sugar and glycogen storage in your body. It takes a few weeks to tap into the fat storage metabolism. Omega3 will help you to properly use your fat storage and keep your kidney function healthy to deal with the fluctuations of daily life.
Potassium
Alcohol
While excessive alcohol consumption can have negative health consequences, consuming alcohol in moderation and in the context of cultural traditions can have some potential health benefits. Here are a few examples:
- Reduced risk of heart disease: Studies have found that moderate alcohol consumption, particularly of red wine, may reduce the risk of heart disease by increasing levels of “good” HDL cholesterol, improving blood flow, and reducing inflammation in the arteries.
- Improved cognitive function: Some studies have suggested that moderate alcohol consumption may improve cognitive function and reduce the risk of cognitive decline and dementia in older adults.
- Social benefits: In many cultures, alcohol is consumed as part of social gatherings and celebrations. Enjoying alcohol in moderation in the context of social interactions and cultural traditions can provide a sense of community and social support.
- Stress reduction: In moderation, alcohol can have a calming effect and may help reduce stress and anxiety.
It’s important to note that these potential benefits are associated with moderate alcohol consumption and may not apply to heavy or binge drinking. Consuming excessive amounts of alcohol can lead to a range of negative health consequences, including liver disease, increased risk of cancer, and mental health issues.
Hangovers after drinking wine, like other alcoholic beverages, are caused by a combination of factors, including dehydration, the presence of toxic byproducts from alcohol metabolism, and inflammation.
Alcohol is a diuretic, meaning that it increases urine production and can lead to dehydration if not enough fluids are consumed. Dehydration can cause symptoms such as headache, dry mouth, and dizziness, which are commonly experienced during a hangover.
Alcohol is also broken down in the liver into a toxic substance called acetaldehyde, which can cause damage to cells and tissues in the body. The buildup of acetaldehyde can contribute to hangover symptoms such as nausea, vomiting, and headache.
In addition, alcohol consumption can trigger an inflammatory response in the body, which can lead to symptoms such as fatigue, muscle aches, and difficulty concentrating.
The specific causes and severity of hangovers can vary depending on factors such as the amount of alcohol consumed, the individual’s tolerance and sensitivity to alcohol, and other lifestyle factors such as diet and hydration.
Alcohol consumption can also contribute to weight gain and obesity in several ways. Here are a few examples:
- Increased calorie intake: Alcoholic beverages contain calories, and drinking can contribute to overall calorie intake. For example, a standard beer contains around 150 calories, while a glass of wine contains around 120-150 calories. Consuming multiple drinks in one sitting can quickly add up to a significant amount of calories.
- Disruption of metabolism: Alcohol consumption can interfere with the body’s metabolism of carbohydrates, leading to increased insulin resistance and fat storage.
- Increased appetite: Drinking alcohol can stimulate the appetite and lead to overeating or snacking on high-calorie foods.
- Poor food choices: Alcohol consumption can impair judgment and decision-making, leading to poorer food choices and a tendency to consume high-calorie, unhealthy foods.
Overall, while moderate alcohol consumption may not lead to significant weight gain, excessive drinking or binge drinking can contribute to obesity and other negative health consequences. If you’re looking to manage your weight or improve your health, reducing or eliminating alcohol consumption may be a helpful strategy.
Alcohol Toxicity
Some people may experience an adverse reaction to sulfites, which can lead to symptoms such as headache, hives, or difficulty breathing. However, sulfite sensitivity is relatively rare, affecting only about 1% of the general population and 5-10% of people with asthma.
The use of sulfites in wine is regulated by law in many countries, including the United States, where wines containing more than 10 parts per million of sulfites must be labeled with the statement “contains sulfites.” The European Union requires similar labeling for wines containing more than 10 mg/L of sulfites.
It’s worth noting that while sulfites are sometimes blamed for wine hangovers, they are not actually a primary cause of hangovers. The symptoms of a wine hangover are more likely to be caused by other factors such as dehydration, alcohol metabolism, and inflammation.
However, when alcohol is consumed in large amounts or over a prolonged period of time, the liver may not be able to process acetaldehyde quickly enough, leading to a buildup of acetaldehyde in the body. This buildup can cause oxidative stress and inflammation in various organs, including the liver, brain, and digestive system.
In addition, alcohol consumption can also trigger an inflammatory response in the body, as the immune system tries to fight off the toxic effects of alcohol and its metabolites. This immune response can lead to the release of inflammatory cytokines, which can cause symptoms such as fatigue, muscle aches, and difficulty concentrating.
One factor that can contribute to differences in hangover severity between different types of alcoholic drinks is the presence of congeners. Congeners are natural byproducts of the fermentation and aging process that give different alcoholic drinks their distinctive flavors and colors. Darker alcohols such as red wine, brandy, and whiskey tend to have higher levels of congeners than lighter alcohols such as white wine and vodka.
Congeners can contribute to hangover symptoms in several ways. They can cause headaches, nausea, and other symptoms by irritating the lining of the stomach or blood vessels in the brain. They can also slow down the metabolism of alcohol, causing it to stay in the body longer and leading to more severe hangover symptoms.
In addition, different people may have varying levels of sensitivity to different types of alcohol, based on individual differences in genetics, metabolism, and other factors. Some people may be more prone to hangovers from certain types of alcohol, while others may be more resilient.
It’s also worth noting that while certain types of alcoholic drinks may be associated with worse hangovers, other lifestyle factors such as dehydration, lack of sleep, and poor diet can also contribute to hangover severity.
Different types of alcoholic drinks contain varying amounts and types of congeners. For example, dark-colored drinks such as red wine, brandy, and whiskey tend to have higher levels of congeners than lighter-colored drinks such as white wine and vodka. Some examples of congeners include methanol, acetone, and acetaldehyde.
Congeners can contribute to hangover symptoms in several ways. They can irritate the lining of the stomach or blood vessels in the brain, leading to headaches, nausea, and other symptoms. They can also slow down the metabolism of alcohol, causing it to stay in the body longer and leading to more severe hangover symptoms.
However, it’s important to note that not all hangover symptoms are caused by congeners. Other factors such as dehydration, sleep deprivation, and inflammation can also contribute to the severity of hangovers. Additionally, not all individuals experience hangovers in the same way, and some people may be more sensitive to certain types of congeners than others.
The liver is responsible for processing and metabolizing alcohol, and chronic alcohol consumption can lead to changes in liver function and the expression of enzymes such as cytochrome P450 (CYP450).
CYP450 enzymes are responsible for metabolizing many drugs, toxins, and other compounds in the body, including alcohol. Chronic alcohol consumption can induce the expression of certain CYP450 enzymes, leading to increased alcohol metabolism and tolerance. However, this increased metabolism can also lead to the production of toxic byproducts such as acetaldehyde, which can cause liver damage and other negative health consequences.
Over time, chronic alcohol consumption can also lead to liver inflammation, scarring, and other liver diseases such as cirrhosis. These changes can further affect liver function and the metabolism of drugs and other compounds in the body.
While the liver can adapt to chronic alcohol consumption to some extent, it’s important to note that excessive drinking or binge drinking can still lead to significant liver damage and negative health consequences. In general, the current scientific consensus is that moderate alcohol consumption, if any, is recommended for most individuals to minimize the risk of alcohol-related liver disease and other health problems.
When cells die, they release cellular debris and damage-associated molecular patterns (DAMPs) that can trigger an inflammatory response in the body. The immune system recognizes these signals as danger signals and releases cytokines to recruit immune cells to the site of tissue damage or infection. This immune response can lead to inflammation and tissue damage.
In addition, alcohol can also directly activate immune cells such as macrophages and dendritic cells, leading to the production of pro-inflammatory cytokines. These cytokines can then contribute to inflammation and tissue damage, further exacerbating the effects of alcohol consumption.
Overall, alcohol consumption can lead to cell death, release of DAMPs and other inflammatory signals, and activation of immune cells, all of which can contribute to cytokine inflammation and tissue damage.
Hormesis is a biological phenomenon in which exposure to low doses of a stressor, such as toxins or radiation, can actually stimulate beneficial adaptations and lead to improved health and longevity. There is some evidence to suggest that mild alcohol consumption may induce hormetic effects by stimulating the body’s cellular stress response mechanisms.
However, it’s worth noting that the hormetic effects of alcohol consumption are likely to be dose-dependent and vary based on individual differences in genetics, lifestyle, and other factors. Consuming excessive amounts of alcohol can lead to cell damage and death, inflammation, and other negative health consequences, which outweigh any potential hormetic benefits.
Coffee ‘filtered’ vs espresso
Coffee is a rich source of antioxidants, which are compounds that help neutralize free radicals in the body, reducing oxidative stress and potentially lowering the risk of various chronic diseases. The main antioxidants found in coffee are chlorogenic acids, hydroxycinnamic acids, melanoidins, and caffeine. Here is more information on the antioxidant benefits of coffee:
- Chlorogenic acids: These are a group of phenolic compounds that are abundant in coffee. Chlorogenic acids have antioxidant properties and have been shown to possess anti-inflammatory, antibacterial, and antiviral effects. They may help reduce the risk of cardiovascular diseases, improve blood sugar regulation, and support weight management.
- Hydroxycinnamic acids: Hydroxycinnamic acids, such as caffeic and ferulic acid, are another group of antioxidants found in coffee. They have been shown to exhibit anti-inflammatory, antiviral, and anticancer properties. These compounds may contribute to the protective effects of coffee on the cardiovascular system and may help reduce the risk of certain types of cancer.
- Melanoidins: Melanoidins are formed during the roasting process of coffee beans, and their levels increase with the degree of roasting. They contribute to the color, flavor, and aroma of coffee. Melanoidins have antioxidant properties and can also chelate (bind to) metal ions, reducing the pro-oxidant effects of these metals in the body.
- Caffeine: While caffeine is best known for its stimulant effects, it also has antioxidant properties. Caffeine can help neutralize free radicals and may protect against neurodegenerative diseases like Parkinson’s and Alzheimer’s disease.
Regular coffee consumption has been associated with various health benefits, which may be partially attributed to its antioxidant content. Some studies have linked moderate coffee consumption to a reduced risk of chronic diseases, such as heart disease, stroke, type 2 diabetes, and certain types of cancer. However, it’s essential to consume coffee in moderation, as excessive intake can have adverse effects, particularly in individuals sensitive to caffeine.
It’s worth noting that the antioxidant content and potential benefits of coffee can be influenced by factors such as the type of coffee beans, the roasting process, and the brewing method. Additionally, adding large amounts of sugar, cream, or flavored syrups to coffee can negate some of its health benefits.
Filtered coffee and espresso differ in their brewing methods, which in turn affects their chemical constituents, including caffeine content, acidity, and antioxidant compounds. Here are some of the main differences:
- Caffeine content: Espresso generally has a higher concentration of caffeine per ounce compared to filtered coffee. However, espresso servings are smaller, which usually results in a lower total caffeine content per cup. A typical 1-ounce espresso shot contains around 63 milligrams of caffeine, while an 8-ounce cup of filtered coffee can have about 95 milligrams of caffeine.
- Acidity: Filtered coffee tends to have a higher acidity level compared to espresso. This is because the longer brewing process of filtered coffee allows more acidic compounds to be extracted from the coffee grounds. Espresso’s shorter brewing time and high pressure result in a lower extraction of acidic compounds, making it less acidic overall.
- Antioxidants and other compounds: Both brewing methods extract different compounds from coffee beans, resulting in varying levels of antioxidants and other chemicals. Espresso usually has a higher concentration of antioxidant compounds, such as chlorogenic acids, due to the high-pressure extraction process. However, filtered coffee also contains antioxidants and can even have higher levels of certain compounds, such as melanoidins, which contribute to the coffee’s flavor and aroma.
- Oils and solids: Espresso has a higher concentration of coffee oils and fine solids, which contribute to its characteristic crema and fuller body. The use of paper filters in the brewing of filtered coffee can capture some of the oils and fine solids, resulting in a cleaner and lighter body.
In summary, filtered coffee and espresso differ in their chemical constituents due to the differences in their brewing methods. Espresso tends to have a higher concentration of caffeine per ounce, a lower acidity level, and a higher concentration of antioxidant compounds, while filtered coffee has a lighter body and higher acidity. The choice between the two depends on personal taste preferences and desired caffeine content.
In Traditional Chinese Medicine (TCM), coffee is not typically included as a traditional remedy or medicinal herb. However, TCM practitioners may still consider the effects of coffee on the body based on its energetic properties and the principles of Yin and Yang.
From a TCM perspective, coffee is considered to have the following properties:
- Warm and dry nature: Coffee is considered to have a warming and drying effect on the body. It can help dispel coldness and dampness, which are linked to various health issues in TCM. However, for individuals with an excess of heat or dryness in their body, coffee consumption could exacerbate these imbalances, potentially leading to symptoms such as irritability, restlessness, insomnia, or digestive issues.
- Stimulating effect: Coffee’s stimulating effect on the nervous system, attributed to its caffeine content, can be seen as a means to invigorate Qi (vital energy) and dispel stagnation. However, excessive consumption of coffee can lead to an overstimulation of Qi and may eventually deplete the body’s energy reserves, causing fatigue, adrenal exhaustion, or sleep disturbances.
- Impact on the Liver: In TCM, the Liver is responsible for the smooth flow of Qi and blood throughout the body. Coffee’s stimulating effects can initially promote the flow of Liver Qi, but over time, excessive consumption can lead to Liver Qi stagnation, manifesting as irritability, mood swings, or headaches.
- Effects on digestion: Coffee is considered to have a stimulating effect on digestion in TCM, promoting the movement of the digestive system and potentially relieving constipation. However, its warming and drying nature can also lead to digestive imbalances, such as increased acidity, stomach pain, or diarrhea, particularly in those with a sensitive digestive system.
In summary, Traditional Chinese Medicine does not classify coffee as a traditional remedy or medicinal herb. However, TCM practitioners may consider its energetic properties when evaluating its effects on an individual’s health. Coffee consumption may have both positive and negative effects, depending on a person’s unique body constitution and balance of Yin and Yang. It’s essential to consume coffee in moderation and be mindful of any adverse effects on your body.
What about tea?
Caffeine is a naturally occurring stimulant found in varying quantities in the leaves, seeds, and fruits of some plants, including coffee, black tea, and green tea. The caffeine molecule itself is the same across these beverages, but the concentration and accompanying compounds in each drink are different, which can affect how the caffeine is absorbed and experienced by the body.
- Coffee: Coffee typically contains the highest concentration of caffeine compared to black tea and green tea. An 8-ounce cup of brewed coffee contains about 95 milligrams of caffeine on average, although this can vary depending on factors such as the type of coffee bean, roast level, and brewing method. Coffee also contains other compounds like chlorogenic acids, which can influence caffeine absorption and metabolism.
- Black tea: Black tea contains less caffeine than coffee but more than green tea. An 8-ounce cup of brewed black tea contains about 47 milligrams of caffeine on average. Black tea also contains a group of compounds called theaflavins and thearubigins, which can affect how the body processes caffeine.
- Green tea: Green tea has the lowest caffeine content among the three beverages. An 8-ounce cup of brewed green tea contains about 28 milligrams of caffeine on average. Green tea is rich in catechins, particularly epigallocatechin gallate (EGCG), which can influence caffeine absorption and metabolism.
Additionally, both black and green tea contain the amino acid L-theanine, which can modulate the effects of caffeine. L-theanine promotes relaxation without causing drowsiness and can reduce the jitteriness and anxiety sometimes associated with caffeine consumption. This combination of caffeine and L-theanine in tea can result in a more sustained and smoother energy boost compared to the more abrupt and intense effect of caffeine in coffee.
In summary, the caffeine molecule is the same in coffee, black tea, and green tea, but the concentration and accompanying compounds in each beverage are different. These differences can affect how the caffeine is absorbed and experienced, with coffee providing the highest caffeine content, followed by black tea and green tea.
Caffeine absorption can differ between coffee and tea, mainly due to the presence of various compounds in each beverage that can influence how the body processes caffeine.
The absorption of caffeine from coffee and tea occurs primarily in the small intestine, but the presence of different compounds in each beverage can affect the rate of absorption and the overall effects of caffeine on the body. One of the main differences between coffee and tea is the presence of L-theanine, an amino acid found in tea but not in coffee.
L-theanine can modulate the effects of caffeine by promoting relaxation without causing drowsiness. It has been found to reduce the jitteriness and anxiety sometimes associated with caffeine consumption, as well as improve focus and attention. The combination of caffeine and L-theanine in tea results in a more sustained and smoother energy boost compared to the more abrupt and intense effect of caffeine in coffee.
If you find that your heart rate is more sensitive to tea than coffee, it could be due to a few factors:
- Individual sensitivity: People have varying sensitivities to caffeine and its effects. You might be more sensitive to the combination of caffeine and other compounds in tea than to caffeine in coffee.
- Caffeine content: Different types and brands of tea can have varying amounts of caffeine, which could affect your heart rate. It’s important to note that some types of tea, such as green or white tea, generally have less caffeine than black tea or coffee.
- Brewing method: The way you prepare your tea or coffee can also affect the caffeine content and its effects on your body. Steeping tea for a longer time or using more tea leaves can result in a higher caffeine content in your tea.
- Consumption habits: How much tea or coffee you consume, as well as the timing of consumption, can influence your heart rate response to caffeine.
It’s essential to be mindful of your body’s reaction to caffeine in various forms and adjust your consumption accordingly. If you find that your heart rate is more sensitive to tea, you might consider reducing the amount of tea you drink, using a lower-caffeine tea, or adjusting the brewing method to reduce the caffeine content.
In Traditional Chinese Medicine (TCM), black tea and green tea are considered to have different properties and are used for different purposes. The primary difference between the two lies in the way they are processed. Green tea is minimally oxidized, preserving its green color and fresh flavor, while black tea undergoes full oxidation, resulting in a darker color and more robust flavor.
Black tea (红茶, hóngchá): In TCM, black tea (or red tea as it is red after brewing) is considered to have a warming effect on the body, making it suitable for people with cold or deficient constitutions. It is believed to nourish the kidneys, support digestion, and help dispel dampness and cold from the body. Some TCM practitioners also attribute blood tonifying properties to black tea, which may be beneficial for individuals with anemia or those recovering from illness or blood loss.
Green tea (绿茶, lǜchá): Green tea, on the other hand, is considered to have a cooling effect on the body. It is believed to be beneficial for people with excessive heat, such as those experiencing inflammation, irritability, or redness in the eyes. Green tea is thought to support liver function, help detoxify the body, and promote mental clarity. Some TCM practitioners also claim that green tea can aid in weight loss by promoting digestion and reducing the accumulation of dampness and phlegm in the body.
It is important to note that TCM is a holistic system of medicine, and the choice between black and green tea should be based on an individual’s overall constitution, health concerns, and preferences. Consulting with a TCM practitioner can provide personalized guidance on the appropriate tea choice and other lifestyle factors to support one’s health and well-being.
It’s worth mentioning that both black and green tea contain antioxidants, polyphenols (discussed below), and other bioactive compounds that have been studied for their potential health benefits in Western medicine. However, the specific effects of each type of tea may vary due to differences in processing and chemical composition.
Biochemistry of caffeine
Caffeine is primarily metabolized in the liver by the cytochrome P450 (CYP) enzyme system, specifically by the CYP1A2 enzyme. The CYP1A2 enzyme is responsible for breaking down about 95% of the caffeine ingested. The process involves three primary steps:
- Demethylation: Caffeine undergoes demethylation, where the CYP1A2 enzyme removes one or more methyl groups from the caffeine molecule. This process results in the formation of three primary metabolites: paraxanthine (84%), theobromine (12%), and theophylline (4%).
- Further metabolism: Each of these primary metabolites undergoes further metabolism by other enzymes in the liver, leading to the formation of secondary metabolites.
- Excretion: Ultimately, these metabolites are excreted through urine, with less than 3% of the ingested caffeine excreted unchanged.
The rate of caffeine metabolism can vary greatly among individuals due to genetic factors, lifestyle, and environmental influences. Some people have a higher or lower CYP1A2 activity, which can affect how quickly they metabolize caffeine. Factors that can influence CYP1A2 activity and, therefore, caffeine metabolism, include:
- Genetic variations: Some individuals have genetic polymorphisms that can result in faster or slower caffeine metabolism.
- Age: Caffeine metabolism tends to be slower in infants, young children, and the elderly compared to healthy adults.
- Smoking: Cigarette smoking can induce CYP1A2 activity, leading to faster caffeine metabolism.
- Medications and other substances: Some medications or substances can inhibit or induce CYP1A2 activity, affecting caffeine metabolism. For example, fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), can inhibit CYP1A2, while the herb St. John’s wort can induce its activity.
- Liver function: Individuals with impaired liver function may have a reduced capacity to metabolize caffeine.
- Hormonal status: Estrogen can inhibit CYP1A2 activity, leading to slower caffeine metabolism in women using oral contraceptives or during pregnancy.
These factors can all impact an individual’s sensitivity to caffeine and the duration of its effects. It’s important to be aware of your own caffeine metabolism and adjust your consumption accordingly to minimize any potential adverse effects.
Studies on paraxanthine, theobromine, and theophylline are the primary metabolites of caffeine. Each of these compounds has distinct physiological effects and has been studied for their potential benefits and drawbacks.
- Paraxanthine (1,7-dimethylxanthine): Paraxanthine is the most abundant metabolite of caffeine, accounting for about 84% of the caffeine metabolites. It has similar properties to caffeine, such as stimulating the central nervous system, increasing heart rate, and promoting lipolysis (breakdown of fats). Some studies have investigated the potential effects of paraxanthine on exercise performance, cognitive function, and mood, although the findings are less robust than those for caffeine.
- Theobromine (3,7-dimethylxanthine): Theobromine is found primarily in cocoa and chocolate and accounts for about 12% of caffeine metabolites. It has mild stimulant properties, but its effects are weaker than those of caffeine. Theobromine has been studied for its potential cardiovascular benefits, such as vasodilation (widening of blood vessels) and blood pressure reduction. Some research has also suggested that theobromine may have mood-enhancing effects, although more studies are needed to confirm these findings.
- Theophylline (1,3-dimethylxanthine): Theophylline is a minor metabolite of caffeine, accounting for about 4% of the metabolites. It has been used for decades as a bronchodilator for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Theophylline relaxes the smooth muscles in the airways, helping to relieve constriction and improve breathing. Its use has declined in recent years due to the development of newer and more selective medications with fewer side effects.
Overall, while these metabolites of caffeine have been studied for their potential effects, their impact is generally less pronounced than that of caffeine itself. The specific effects of each compound can vary depending on factors such as concentration, individual sensitivity, and interactions with other substances.
Fluoride
The long standing question if fluoride additives or treatments are safe remains. The consensus however is, that fluoride additives are considered toxic to the bodies’ enzymes and even carcinogenic as explained below. Natural fluoride levels are much lower than 0.7mg/L and areas with high levels clearly show health risks. There are much safer ways of ensuring proper dental health.
Natural Fluoride Levels in Water:
The natural fluoride concentration in water varies greatly depending on geographic location however it is generally very low, soil composition, and groundwater sources.
- Typical Levels: In most natural freshwater sources, fluoride concentrations range from 0.01 to 0.3 mg/L. These levels are usually too low to have a significant dental impact without supplementation.
- High Fluoride Areas: In some areas with high levels of fluoride-rich minerals, such as certain parts of India, China, Africa, and the southwestern United States, natural fluoride levels in groundwater can reach 1 to 10 mg/L or higher. These areas are more prone to fluoride-related health issues like fluorosis due to the higher concentration of fluoride.
Natural Fluoride Levels in Plants:
Plants absorb fluoride from the soil and water, so fluoride content in plants depends on soil levels, water irrigation sources, and the type of plant.
- Leafy Vegetables: Plants like tea leaves are known to accumulate higher fluoride levels. Tea leaves, for instance, can contain between 1 to 10 mg/kg of fluoride due to their ability to absorb fluoride from soil and water over long periods.
- Other Crops: Fluoride levels in most edible crops like fruits, vegetables, and grains generally range from 0.1 to 1 mg/kg in low-fluoride areas. However, in regions with naturally high fluoride in soil or irrigation water, these concentrations can be higher.
- Food Processing Effects: Some processed foods and beverages, especially tea and dried foods reconstituted with fluoridated water, may also have elevated fluoride levels due to the water used in preparation.
Summary:
- Water: Natural fluoride levels are generally 0.01-0.3 mg/L in most water sources, with higher concentrations (up to 10 mg/L or more) in areas with fluoride-rich geology.
- Plants: Typical fluoride levels are 0.1-1 mg/kg for most crops but can be as high as 1-10 mg/kg in tea leaves or in plants grown in high-fluoride areas.
High fluoride levels in water or soil, particularly in certain regions, can lead to higher fluoride content in plants and foods, potentially impacting local populations’ exposure.
Fluoride can be toxic in high doses primarily because it interferes with biological processes at the cellular level and can accumulate in the body over time. Here’s an overview of why fluoride has toxic effects:
1. Cellular Toxicity and Enzyme Inhibition:
- Fluoride ions interfere with cellular enzymes by binding to magnesium and calcium ions within the cells, which are critical for enzyme function. Enzymes like enolase, which plays a role in glucose metabolism, are inhibited by high levels of fluoride. This interference disrupts energy production, impacting cellular function and leading to cellular damage at high doses.
- Fluoride can also generate reactive oxygen species (ROS) in the body, contributing to oxidative stress, which damages cells and tissues and is associated with various diseases, including neurotoxicity and kidney damage.
2. Bone and Teeth Accumulation:
- Fluoride accumulates in bones and teeth, which can lead to skeletal fluorosis and dental fluorosis at high exposure levels. In skeletal fluorosis, excessive fluoride in bones causes them to become denser but more brittle, leading to pain, stiffness, and an increased risk of fractures. Dental fluorosis results in mottling or discoloration of teeth due to excessive fluoride intake during tooth development.
3. Impact on Nervous System:
- Some studies suggest that high levels of fluoride exposure can have neurotoxic effects, particularly in children. High fluoride levels are associated with developmental neurotoxicity, potentially affecting memory, learning, and IQ, though this primarily concerns areas where fluoride concentrations are much higher than in fluoridated drinking water.
4. Thyroid Function:
- Fluoride can affect thyroid function by disrupting the production of thyroid hormones, especially when iodine intake is low. Historically, fluoride was used in very high doses to treat hyperthyroidism, as it can lower thyroid hormone levels, but this is not a common practice today due to its side effects and toxicity.
Toxic Levels and Safe Limits:
- The toxic effects of fluoride depend on the dose and duration of exposure. Low doses, like those used in public water fluoridation (0.7 mg/L), are generally considered safe for dental health without significant adverse effects. Toxicity typically arises from prolonged exposure to high levels, such as from industrial contamination, natural fluoride deposits in water, or overuse of fluoride-containing products.
In summary, fluoride becomes toxic at high doses due to its ability to disrupt enzyme function, accumulate in bones and teeth, generate oxidative stress, and potentially impact the nervous and endocrine systems.
Polyphenols and Insulin
Polyphenols have many benefits. There have been numerous studies examining the α-glucosidase inhibitory effects of polyphenols found in fruits, teas, and other plant-based foods. Remember that reducing inflammation is key and the metabolism can be slowed down but the root of these problems lie within “metabolic disease” discussed in the Omega3 section. Science – Omega3 Science Explained (omega3health.us)
Olive polyphenols, particularly those found in olive oil, have been widely studied for their health benefits. These benefits stem largely from their antioxidant, anti-inflammatory, and antimicrobial properties.
- Heart Health: Olive polyphenols, especially those in extra virgin olive oil, are known for their cardioprotective properties. They can improve heart health by reducing inflammation, lowering blood pressure, improving cholesterol levels (by increasing HDL cholesterol and decreasing LDL cholesterol oxidation), and reducing the risk of thrombosis.
- Antioxidant Properties: Polyphenols are powerful antioxidants that protect cells from oxidative stress and damage caused by free radicals. This antioxidant action can contribute to the prevention of various chronic diseases, including cardiovascular diseases and cancer.
- Anti-inflammatory Effects: Chronic inflammation is a root cause of many diseases, and olive polyphenols have demonstrated anti-inflammatory effects. Oleuropein and hydroxytyrosol, in particular, have been shown to inhibit inflammatory pathways.
- Cancer Prevention: Some studies suggest that olive polyphenols may help reduce the risk of certain types of cancer. This protective effect is likely due to their antioxidant properties, ability to modulate gene expression, and potential to induce apoptosis (programmed cell death) in cancer cells.
- Neuroprotective Effects: Olive polyphenols may have beneficial effects on brain health. Their antioxidant and anti-inflammatory properties could play a role in protecting against neurodegenerative diseases like Alzheimer’s and Parkinson’s disease.
- Type 2 Diabetes Management: Polyphenols in olive oil can help improve insulin sensitivity and stabilize blood sugar levels, which are beneficial for individuals with type 2 diabetes or those at risk.
- Gut Health: The antimicrobial properties of olive polyphenols can influence gut health by affecting the growth of bacteria in the gut microbiome. Additionally, their anti-inflammatory effects can be beneficial for gastrointestinal health.
- Bone Health: Emerging research suggests that olive polyphenols may have a positive impact on bone health by reducing bone loss and promoting bone formation, potentially offering protection against osteoporosis.
- Skin Health: Topically applied olive polyphenols or those ingested through diet can benefit skin health. They can protect the skin from oxidative damage, improve skin elasticity, and have anti-aging effects.
It’s important to note that while the potential health benefits of olive polyphenols are supported by a growing body of research, these findings are based on a combination of laboratory, animal, and some human studies. Moreover, the best health benefits are often associated with consuming olive products as part of a balanced, Mediterranean-style diet.
Inhibiting α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) are strategies that have been explored in the context of improving insulin sensitivity and managing conditions like type 2 diabetes.
- α-Glucosidase Inhibition:
- Function: α-Glucosidase is an enzyme in the small intestine responsible for breaking down complex carbohydrates into simple sugars. This process is a key step in carbohydrate digestion and subsequent glucose absorption into the bloodstream.
- Inhibition and Blood Sugar Control: Inhibiting α-glucosidase slows down the breakdown of carbohydrates, which in turn slows glucose absorption. This results in a more gradual increase in blood sugar levels after meals, helping to prevent spikes in blood sugar which are common in diabetes.
- Medications and Natural Inhibitors: Several medications used in the management of type 2 diabetes, such as acarbose, are α-glucosidase inhibitors. Additionally, certain dietary components, like polyphenols found in various fruits and teas, have also been shown to inhibit α-glucosidase.
- Chinese Herbs are used extensively for the treatment of insulin sensitivity – check here!
- Protein Tyrosine Phosphatase 1B (PTP1B) Inhibition:
- Function: PTP1B is an enzyme that negatively regulates insulin signaling pathways. It dephosphorylates the insulin receptor and the insulin receptor substrate, which are crucial for insulin signal transduction in cells.
- Inhibition and Insulin Sensitivity: Inhibiting PTP1B can enhance insulin signaling, thereby potentially improving insulin sensitivity and helping to manage high blood sugar levels.
- Research and Development: There is ongoing research to develop PTP1B inhibitors as potential therapeutic agents for diabetes and obesity. However, as of 2023, no PTP1B inhibitors have been approved for clinical use. One challenge is achieving specificity, as PTP1B shares structural similarities with other phosphatases, and non-specific inhibition could lead to unintended side effects.
Implications in Diabetes Management:
- Both α-glucosidase and PTP1B play significant roles in glucose metabolism and insulin signaling. Therapeutic strategies targeting these enzymes could be beneficial for improving glycemic control and insulin sensitivity in individuals with type 2 diabetes or prediabetes.
- However, it’s important to note that these strategies should be part of a comprehensive approach to diabetes management, which also includes lifestyle modifications such as diet, exercise, and weight management.
1. Tea Polyphenols:
– A study titled “Green Tea Polyphenols: Novel and Potent Inhibitors of Squalene Epoxidase” (Biochemical and Biophysical Research Communications, 2000) discusses how green tea polyphenols, particularly catechins, exhibit α-glucosidase inhibitory activity.
– Another research paper, “Inhibitory Effect of Green Tea and Black Tea on the Metabolism of n-Nitrosodimethylamine: Evidence Against the Inhibition as a Mechanism for the Chemoprevention of Cancer” (Biochemical Pharmacology, 2000), explores the inhibitory effects of both green and black tea polyphenols.
2. Fruit Polyphenols:
– Research titled “Berry Polyphenols and Their Effect on Carbohydrate Digestion and Absorption: A Review” (Journal of Agricultural and Food Chemistry, 2013) provides insight into how polyphenols in berries can inhibit α-glucosidase.
– “Inhibitory Effects of Apple Polyphenols and Related Compounds on Carcinogen-activating Enzymes” (Journal of Agricultural and Food Chemistry, 2000) discusses the effects of apple polyphenols.
3. Polyphenols in Other Foods:
– The study “Cinnamon Extract Inhibits α-Glucosidase Activity and Dampens Postprandial Glucose Excursions in Diabetic Rats” (Nutrition & Metabolism, 2012) explores the impact of cinnamon, another source of polyphenols, on α-glucosidase.
– “Inhibitory Activity of a Standardized Extract from Eriobotrya japonica Against α-Glucosidase and Its Use for Reducing Postprandial Hyperglycemia” (Phytotherapy Research, 2010) looks at loquat fruit extracts.
Olive polyphenols, like those found in olive oil, leaves, and the fruit itself, are recognized for their health benefits, which include antioxidant, anti-inflammatory, and cardioprotective effects. While the specific types of polyphenols in olives may differ from those found in teas and berries, some olive polyphenols have also been studied for their potential to inhibit α-glucosidase, an enzyme involved in carbohydrate digestion.
Here are some key points regarding olive polyphenols and α-glucosidase inhibition:
- Different Polyphenol Profiles: Olives and olive oil are rich in polyphenols like oleuropein, hydroxytyrosol, and tyrosol, which are different from the catechins found in tea or the anthocyanins in berries. Each type of polyphenol has a unique chemical structure and may interact differently with biological targets like enzymes.
- Studies on Olive Polyphenols: Research has investigated the effects of olive polyphenols on α-glucosidase. For instance, oleuropein, a major polyphenol in olive leaves, has demonstrated α-glucosidase inhibitory activity in some studies. These findings suggest a potential role for olive polyphenols in managing blood sugar levels, particularly postprandial glucose levels.
- Mechanisms of Action: The exact mechanisms by which olive polyphenols inhibit α-glucosidase may involve direct interaction with the enzyme, altering its structure or function. The antioxidant properties of these polyphenols may also contribute to their overall health benefits, including glycemic control.
- Context of Consumption: It’s important to consider that the health effects of polyphenols can be influenced by how they are consumed. In the case of olives and olive oil, factors like the type of olive, processing methods, and the presence of other food components can affect polyphenol content and bioavailability.
- Research and Clinical Implications: While the initial research is promising, more studies, particularly clinical trials, are needed to fully understand the impact of olive polyphenols on α-glucosidase and their practical implications for dietary recommendations and diabetes management.
In summary, while olive polyphenols are different from those found in teas and berries, some of them have shown potential for α-glucosidase inhibition, which could be beneficial for blood sugar regulation.
To do your own research you can visit PubMed : enter relevant keywords such as “polyphenols α-glucosidase inhibition” or “tea fruit polyphenols diabetes.” These studies provide valuable insights into the potential health benefits of dietary polyphenols, particularly in relation to carbohydrate digestion and glucose metabolism, which are key areas of interest in managing conditions like diabetes.
Disclaimer: The author tries to diligently cite publications on this vast topic but makes no health claims. Please visit frequently as this topic is complex and growing scientific data daily. Permission to copy content herein is requested.